| |  Online-Ressource |
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| Verfasst von: | Lukassen, Sören [VerfasserIn]  |
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| | Chua, Robert Lorenz [VerfasserIn] |
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| | Trefzer, Timo [VerfasserIn] |
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| | Kahn, Nicolas [VerfasserIn] |
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| | Schneider, Marc [VerfasserIn] |
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| | Muley, Thomas [VerfasserIn] |
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| | Winter, Hauke [VerfasserIn] |
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| | Meister, Michael [VerfasserIn] |
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| | Veith, Carmen [VerfasserIn] |
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| | Boots, Agnes W [VerfasserIn] |
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| | Hennig, Bianca P [VerfasserIn] |
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| | Kreuter, Michael [VerfasserIn] |
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| | Conrad, Christian [VerfasserIn] |
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| | Eils, Roland [VerfasserIn] |
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| Titel: | SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells |
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| Verf.angabe: | Soeren Lukassen, Robert Lorenz Chua, Timo Trefzer, Nicolas C Kahn, Marc A Schneider, Thomas Muley, Hauke Winter, Michael Meister, Carmen Veith, Agnes W Boots, Bianca P Hennig, Michael Kreuter, Christian Conrad & Roland Eils |
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| E-Jahr: | 2020 |
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| Jahr: | 14 April 2020 |
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| Fussnoten: | Gesehen am 14.04.2020 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationThe EMBO journal |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 1982 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 39(2020,10) Artikel-Nummer e105114, 39 Seiten |
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| ISSN Quelle: | 1460-2075 |
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| Abstract: | The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and replication. SARS-CoV-2 was reported to enter cells via binding to ACE2, followed by its priming by TMPRSS2. Here, we investigate ACE2 and TMPRSS2 expression levels and their distribution across cell types in lung tissue (twelve donors, 39,778 cells) and in cells derived from subsegmental bronchial branches (four donors, 17,521 cells) by single nuclei and single cell RNA sequencing, respectively. While TMPRSS2 is strongly expressed in both tissues, in the subsegmental bronchial branches ACE2 is predominantly expressed in a transient secretory cell type. Interestingly, these transiently differentiating cells show an enrichment for pathways related to RHO GTPase function and viral processes suggesting increased vulnerability for SARS-CoV-2 infection. Our data provide a rich resource for future investigations of COVID-19 infection and pathogenesis. |
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| DOI: | doi:10.15252/embj.20105114 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.15252/embj.20105114 |
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| | Volltext: https://www.embopress.org/doi/10.15252/embj.20105114 |
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| | DOI: https://doi.org/10.15252/embj.20105114 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | COVID-19 |
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| | epithelial differentiation |
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| | FURIN |
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| | Human Cell Atlas |
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| | respiratory tract |
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| K10plus-PPN: | 1694500993 |
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| Verknüpfungen: | → Zeitschrift |
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SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells / Lukassen, Sören [VerfasserIn]; 14 April 2020 (Online-Ressource)
