Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Kopp, Benedikt [VerfasserIn]   i
 Mein, Stewart [VerfasserIn]   i
 Dokić, Ivana [VerfasserIn]   i
 Harrabi, Semi B. [VerfasserIn]   i
 Böhlen, Till Tobias [VerfasserIn]   i
 Haberer, Thomas [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Abdollahi, Amir [VerfasserIn]   i
 Mairani, Andrea [VerfasserIn]   i
Titel:Development and validation of single field multi-ion particle therapy treatments
Verf.angabe:Benedikt Kopp, Stewart Mein, Ivana Dokic, Semi Harrabi, Till Tobias Böhlen, Thomas Haberer, Jürgen Debus, Amir Abdollahi, Andrea Mairani
Jahr:2020
Jahr des Originals:2019
Umfang:12 S.
Fussnoten:Published online: October 11, 2019 ; Gesehen am 15.04.2020
Titel Quelle:Enthalten in: International journal of radiation oncology, biology, physics
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1975
Jahr Quelle:2020
Band/Heft Quelle:106(2020), 1, Seite 194-205
ISSN Quelle:1879-355X
Abstract:<h3>Purpose</h3><p>To develop and validate combined ion-beam with constant relative biological effectiveness (RBE) (CICR) particle therapy in single field arrangements for improved treatment efficacy, robustness, and normal tissue sparing.</p><h3>Methods and Materials</h3><p>The PRECISE (PaRticle thErapy using single and Combined Ion optimization StratEgies) treatment planning system was developed to investigate clinical viability of CICR treatments. Single-field uniform dose (SFUD) with a single ion (proton [p], helium [He], or carbon [C]) and CICR (C-p and C-He) treatments were generated for 3 patient cases with a clinically prescribed dose of 3 Gy (RBE) per fraction. Spread-out Bragg peak plans were irradiated in homogenous and clinical-like settings using an anthropomorphic head phantom. A dosimetric and biological verification of CICR<sub>C-p</sub> treatments using a murine glioma cell line (GL261) was performed.</p><h3>Results</h3><p>CICR treatment plans for the 3 patients presented highly uniform physical dose while reducing high dose-averaged linear energy transfer gradients compared with carbon ions alone. When considering uncertainty in tissue parameter (α/β)<sub>x</sub> assignment and RBE modeling, the CICR<sub>C-p</sub> treatment exhibited enhanced biophysical stability within the target volume, similar to protons alone. CICR treatments reduced dose to normal tissue surrounding the target, exhibiting similar or improved dosimetric features compared with SFUD<sub>He</sub>. For both CICR<sub>C-p</sub> and SFUD treatments, measurements verified the planned dose in the target within ∼3%. Planned versus measured target RBE values were 1.38 ± 0.02 and 1.39 ± 0.07 (<1% deviation), respectively, for the CICR<sub>C-p</sub> treatment in heterogenous settings.</p><h3>Conclusions</h3><p>Here, we demonstrate that by combining 2 (or more) ions in a single field arrangement, more robust biological and more conformal dose distributions can be delivered compared with conventional particle therapy treatment planning. This work constitutes the first dosimetric and biological verification of multi-ion particle therapy in homogeneous as well as heterogenous settings.</p>
DOI:doi:10.1016/j.ijrobp.2019.10.008
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.ijrobp.2019.10.008
 Volltext: https://www.redjournal.org/article/S0360-3016(19)33879-9/abstract
 DOI: https://doi.org/10.1016/j.ijrobp.2019.10.008
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1694557731
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68564406   QR-Code
zum Seitenanfang