Development and validation of single field multi-ion particle therapy treatments

• Verfasst von: Kopp, Benedikt [VerfasserIn]
• Verfasst von: Mein, Stewart [VerfasserIn]
• Verfasst von: Dokić, Ivana [VerfasserIn]
• Verfasst von: Harrabi, Semi B. [VerfasserIn]
• Verfasst von: Böhlen, Till Tobias [VerfasserIn]
• Verfasst von: Haberer, Thomas [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Abdollahi, Amir [VerfasserIn]
• Verfasst von: Mairani, Andrea [VerfasserIn]
• Titel: Development and validation of single field multi-ion particle therapy treatments
• Verf.angabe: Benedikt Kopp, Stewart Mein, Ivana Dokic, Semi Harrabi, Till Tobias Böhlen, Thomas Haberer, Jürgen Debus, Amir Abdollahi, Andrea Mairani
• Jahr: 2020
• Jahr des Originals: 2019
• Umfang: 12 S.
• Fussnoten: Published online: October 11, 2019 ; Gesehen am 15.04.2020
• Titel Quelle: Enthalten in: International journal of radiation oncology, biology, physics
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2020
• Band/Heft Quelle: 106(2020), 1, Seite 194-205
• ISSN Quelle: 1879-355X
• DOI: doi:10.1016/j.ijrobp.2019.10.008
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1694557731

Abstract

<h3>Purpose</h3><p>To develop and validate combined ion-beam with constant relative biological effectiveness (RBE) (CICR) particle therapy in single field arrangements for improved treatment efficacy, robustness, and normal tissue sparing.</p><h3>Methods and Materials</h3><p>The PRECISE (PaRticle thErapy using single and Combined Ion optimization StratEgies) treatment planning system was developed to investigate clinical viability of CICR treatments. Single-field uniform dose (SFUD) with a single ion (proton [p], helium [He], or carbon [C]) and CICR (C-p and C-He) treatments were generated for 3 patient cases with a clinically prescribed dose of 3 Gy (RBE) per fraction. Spread-out Bragg peak plans were irradiated in homogenous and clinical-like settings using an anthropomorphic head phantom. A dosimetric and biological verification of CICR_C-p treatments using a murine glioma cell line (GL261) was performed.</p><h3>Results</h3><p>CICR treatment plans for the 3 patients presented highly uniform physical dose while reducing high dose-averaged linear energy transfer gradients compared with carbon ions alone. When considering uncertainty in tissue parameter (α/β)_x assignment and RBE modeling, the CICR_C-p treatment exhibited enhanced biophysical stability within the target volume, similar to protons alone. CICR treatments reduced dose to normal tissue surrounding the target, exhibiting similar or improved dosimetric features compared with SFUD_He. For both CICR_C-p and SFUD treatments, measurements verified the planned dose in the target within ∼3%. Planned versus measured target RBE values were 1.38 ± 0.02 and 1.39 ± 0.07 (<1% deviation), respectively, for the CICR_C-p treatment in heterogenous settings.</p><h3>Conclusions</h3><p>Here, we demonstrate that by combining 2 (or more) ions in a single field arrangement, more robust biological and more conformal dose distributions can be delivered compared with conventional particle therapy treatment planning. This work constitutes the first dosimetric and biological verification of multi-ion particle therapy in homogeneous as well as heterogenous settings.</p>