Online-Ressource | |
Verfasst von: | Michels, Judith [VerfasserIn] |
Becker, Natalia [VerfasserIn] | |
Suciu, Stefan [VerfasserIn] | |
Kaiser, Iris [VerfasserIn] | |
Benner, Axel [VerfasserIn] | |
Kosaloglu-Yalcin, Zeynep [VerfasserIn] | |
Agoussi, Sandrine [VerfasserIn] | |
Halama, Niels [VerfasserIn] | |
Pawlita, Michael [VerfasserIn] | |
Waterboer, Tim [VerfasserIn] | |
Eichmüller, Stefan B. [VerfasserIn] | |
Jäger, Dirk [VerfasserIn] | |
Eggermont, Alexander M. M. [VerfasserIn] | |
Zörnig, Inka [VerfasserIn] | |
Titel: | Multiplex bead-based measurement of humoral immune responses against tumor-associated antigens in stage II melanoma patients of the EORTC18961 trial |
Verf.angabe: | Judith Michels, Natalia Becker, Stefan Suciu, Iris Kaiser, Axel Benner, Zeynep Kosaloglu-Yalcin, Sandrine Agoussi, Niels Halama, Michael Pawlita, Tim Waterboer, Stefan B. Eichmüller, Dirk Jäger, Alexander M.M. Eggermont & Inka Zörnig |
E-Jahr: | 2018 |
Jahr: | 12 February 2018 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 15.04.2020 |
Titel Quelle: | Enthalten in: OncoImmunology |
Ort Quelle: | Abingdon : Taylor & Franics, 2012 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 7(2018,6) Artikel-Nummer e1428157, 10 Seiten |
ISSN Quelle: | 2162-402X |
Abstract: | Purpose: Determine the prognostic and predictive significance of tumor associated antigen (TAA)-specific serum antibodies in melanoma patients of a large adjuvant vaccination phase III trial. Patients and methods: Serum IgG antibodies were measured against a panel of 43 antigens by a bead-based multiplex assay in 970 stage II melanoma patients of the EORTC18961 trial, evaluating adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation. Primary end point was relapse-free survival (RFS). Patients' sera at baseline, after 12 and 48 weeks of study treatment and at the last available time point (at recurrence/remission) were evaluated. Results: Prognostic clinical variables are gender, surgical confirmation of lymph node-negative status, Breslow thickness and ulceration of the primary. Prognostic spontaneous antibody responses were associated with a significant dismal (GM2, Rhod_E2, SSX2) or good prognosis (CyclinB1, SCYE1v1) for RFS, distant metastasis-free (DMFS) or overall survival (OS). Predictive spontaneous antibody responses based on significant interaction with treatment were RhodN p = 0.02, Rab38 p = 0.04 for RFS, RhodE2 p = 0.006, Recoverin p = 0.04 for DMFS and RhodE2 p = 0.003; Recoverin p = 0.04, NA17.A p = 0.04, for OS respectively. The subgroups of patients according to antibody responses for RFS were determined for RhodN sero-negative (n = 849, HR = 1.07, p = 0.6); RhodN sero-positive (n = 121,HR = 0.42, p = 0.01) and Rab38 sero-negative (n = 682, HR = 1.12, p = 0.42), Rab38 sero-positive (n = 288, HR = 0.65, p = 0.04) patients respectively. Conclusion: We identified prognostic serum antibody responses against TAA in stage II melanoma patients. A set of antibody responses correlated with a beneficial outcome for GM2 vaccination. |
DOI: | doi:10.1080/2162402X.2018.1428157 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext: https://doi.org/10.1080/2162402X.2018.1428157 |
DOI: https://doi.org/10.1080/2162402X.2018.1428157 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | autoantibody |
ganglioside | |
melanoma | |
multiplex serology | |
rhodopsin | |
K10plus-PPN: | 1694608220 |
Verknüpfungen: | → Zeitschrift |