| |  Online-Ressource |
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| Verfasst von: | Fleming, Viktor [VerfasserIn]  |
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| | Hu, Xiaoying [VerfasserIn] |
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| | Weber, Rebekka [VerfasserIn] |
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| | Groth, Christopher [VerfasserIn] |
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| | Altevogt, Peter [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Umansky, Viktor [VerfasserIn] |
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| Titel: | Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression |
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| Mitwirkende: | Nagibin, Vasyl |
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| Verf.angabe: | Viktor Fleming, Xiaoying Hu, Rebekka Weber, Vasyl Nagibin, Christopher Groth, Peter Altevogt, Jochen Utikal and Viktor Umansky |
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| E-Jahr: | 2018 |
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| Jahr: | 02 March 2018 |
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| Umfang: | 1 S. |
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| Fussnoten: | Gesehen am 15.04.2020 |
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| Titel Quelle: | Enthalten in: Frontiers in immunology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2010 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 9(2018), Artikel-ID 398 |
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| ISSN Quelle: | 1664-3224 |
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| Abstract: | The immune system has many sophisticated mechanisms to balance an extensive immune response. Distinct immunosuppressive cells could protect from excessive tissue damage and autoimmune disorders. Tumor cells take an advantage of those immunosuppressive mechanisms and establish a strongly immunosuppressive tumor microenvironment (TME), which inhibits antitumor immune responses, supporting the disease progression. Myeloid-derived suppressor cells (MDSC) play a crucial role in this immunosuppressive TME. Those cells represent a heterogeneous population of immature myeloid cells with a strong immunosuppressive potential. They inhibit an antitumor reactivity of T cells and NK cells. Furthermore, they promote angiogenesis, establish pre-metastatic niches, and recruit other immunosuppressive cells such as regulatory T cells. Accumulating evidences demonstrated that the enrichment and activation of MDSC correlated with tumor progression, recurrence, and negative clinical outcome. In the last few years, various preclinical studies and clinical trials targeting MDSC showed promising results. In this review, we discuss different therapeutic approaches on MDSC targeting to overcome immunosuppressive TME and enhance the efficiency of current tumor immunotherapies. |
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| DOI: | doi:10.3389/fimmu.2018.00398 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://dx.doi.org/10.3389/fimmu.2018.00398 |
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| | DOI: https://doi.org/10.3389/fimmu.2018.00398 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | cancer immunotherapy |
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| | Clinical Trials as Topic |
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| | Humans |
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| | Immune Tolerance |
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| | immunosuppression |
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| | Immunotherapy |
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| | Killer Cells, Natural |
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| | Lymphocyte Activation |
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| | myeloid-derived suppressor cells |
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| | Myeloid-Derived Suppressor Cells |
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| | Neoplasms |
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| | T-Lymphocytes |
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| | therapeutic targeting |
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| | Tumor Escape |
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| | tumor microenvironment |
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| | Tumor Microenvironment |
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| K10plus-PPN: | 1694609944 |
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| Verknüpfungen: | → Zeitschrift |
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Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression / Fleming, Viktor [VerfasserIn]; 02 March 2018 (Online-Ressource)
