Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Chattopadhyay, Subhayan [VerfasserIn]   i
 Zheng, Guoqiao [VerfasserIn]   i
 Hemminki, Akseli [VerfasserIn]   i
 Försti, Asta [VerfasserIn]   i
 Sundquist, Kristina [VerfasserIn]   i
 Sundquist, Jan [VerfasserIn]   i
 Hemminki, Kari [VerfasserIn]   i
Titel:Influence of family history on risk of second primary cancers and survival in patients with squamous cell skin cancer
Verf.angabe:S. Chattopadhyay, G. Zheng, A. Hemminki, A. Försti, K. Sundquist, J. Sundquist, K. Hemminki
Jahr:2020
Jahr des Originals:2019
Fussnoten:First published: 19 December 2019 ; Gesehen am 15.04.2020
Titel Quelle:Enthalten in: British journal of dermatology
Ort Quelle:Oxford : Wiley-Blackwell, 1892
Jahr Quelle:2020
Band/Heft Quelle:183(2020), 3, Seite 488-494
ISSN Quelle:1365-2133
Abstract:Background Patients with squamous cell skin cancer (SCC) have an excellent prognosis but second primary cancers (SPCs) weaken survival prospects. Family history is a known risk factor for cancer but whether it is a risk factor for SPC in patients with SCC is not known. Objectives To quantify the risk of family history on SPCs in patients with SCC and estimate survival probabilities of patients with SPCs depending on family history. Methods With 13 945 histologically verified SCCs, relative risks (RRs) were estimated for family history using a generalized regression model. For survival analysis, hazard ratios (HRs) were assessed using a multivariable Cox proportional-hazards model. Results Family history of invasive SCC increased risk of second invasive SCC [RR = 42·92, 95% confidence interval (CI) 33·69-50·32] compared with risk without family history (RR 19·12, 95% CI 17·88-21·08). Family history of any nonskin cancer in invasive SCC increased risk of the same cancers to be diagnosed as SPC (RRFH = 1·48, 95% CI 1·35-1·61 vs. RRno FH = 1·40, 95% CI 1·32-1·48); significant increases were observed for seven different nonskin cancers. Most results were replicated for in situ SCC. SPC was deleterious for survival irrespective of family history; HR for patients with SPC was 4·28 (95% CI 3·83-4·72) vs. those without SPC (1·04). Conclusions Family history of nonskin cancer was associated with approximately a doubling of risk for SPCs in patients with SCC. SPC increases the death rate in patients with SCC 3-4 times, irrespective of family history. Taking family history into account at SCC diagnosis may help prevention or early detection of SPCs. What's already known about this topic? Second primary cancers (SPCs) are frequently diagnosed in patients with invasive and in situ squamous cell carcinoma (SCC); some epidemiological studies suggest a link to immune dysfunction. Family history of cancer is a risk factor for practically all first primary cancers but whether it also influences risk of SPCs in patients with SCC is not known. The possible influence of family history on survival in patients with SCC remains to be established.
DOI:doi:10.1111/bjd.18809
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1111/bjd.18809
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18809
 DOI: https://doi.org/10.1111/bjd.18809
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1694611698
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68564656   QR-Code
zum Seitenanfang