| |  Online-Ressource |
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| Verfasst von: | Luft, Thomas [VerfasserIn]  |
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| | Benner, Axel [VerfasserIn] |
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| | Terzer, Tobias [VerfasserIn] |
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| | Jodele, Sonata [VerfasserIn] |
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| | Dandoy, Christopher E. [VerfasserIn] |
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| | Storb, Rainer [VerfasserIn] |
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| | Kordelas, Lambros [VerfasserIn] |
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| | Beelen, Dietrich [VerfasserIn] |
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| | Gooley, Ted [VerfasserIn] |
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| | Sandmaier, Brenda M. [VerfasserIn] |
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| | Sorror, Mohamed [VerfasserIn] |
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| | Zeisbrich, Markus [VerfasserIn] |
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| | Radujkovic, Aleksandar [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Penack, Olaf [VerfasserIn] |
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| Titel: | EASIX and mortality after allogeneic stem cell transplantation |
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| Verf.angabe: | Thomas Luft, Axel Benner, Tobias Terzer, Sonata Jodele, Christopher E. Dandoy, Rainer Storb, Lambros Kordelas, Dietrich Beelen, Ted Gooley, Brenda M. Sandmaier, Mohamed Sorror, Markus Zeisbrich, Aleksandar Radujkovic, Peter Dreger, Olaf Penack |
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| E-Jahr: | 2020 |
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| Jahr: | [2020] |
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| Jahr des Originals: | 2019 |
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| Umfang: | 9 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Published online: 26 September 2019 ; Gesehen am 16.04.2020 |
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| Titel Quelle: | Enthalten in: Bone marrow transplantation |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 55(2020), 3, Seite 553-561 |
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| ISSN Quelle: | 1476-5365 |
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| Abstract: | Allogeneic stem cell transplantation (alloSCT) is an effective immunotherapy in patients with hematological malignancies. Endothelial dysfunction was linked to major complications after alloSCT. We asked the question if the “Endothelial Activation and Stress Index” (EASIX; [(creatinine × LDH) ÷ thrombocytes]) can predict mortality after alloSCT. We performed a retrospective cohort analysis in five alloSCT centers in the USA and Germany. EASIX was assessed prior to conditioning (EASIX-pre) and correlated with mortality in 755 patients of a training cohort in multivariable models. The predictive model established in the training cohort was validated in 1267 adult allo-recipients. Increasing EASIX-pre predicted lower overall survival (OS) after alloSCT, and successful model validation was achieved for the validation cohort. We found that EASIX-pre predicts OS irrespective of established scores. Moreover, EASIX-pre was also a significant prognostic factor for transplant-associated microangiopathy. Finally, EASIX-pre correlated with biomarkers of endothelial homeostasis such as CXCL8, interleukin-18, and insulin-like-growth-factor-1 serum levels. This study establishes EASIX-pre based on a standard laboratory biomarker panel as a predictor of individual risk of mortality after alloSCT independently from established clinical criteria. |
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| DOI: | doi:10.1038/s41409-019-0703-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41409-019-0703-1 |
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| | Volltext: https://www.nature.com/articles/s41409-019-0703-1 |
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| | DOI: https://doi.org/10.1038/s41409-019-0703-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1694665593 |
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| Verknüpfungen: | → Zeitschrift |
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EASIX and mortality after allogeneic stem cell transplantation / Luft, Thomas [VerfasserIn]; [2020] (Online-Ressource)
