Heteroatom‐interchanged isomers of lissoclinamide 5

• Verfasst von: Xie, Sida [VerfasserIn]
• Verfasst von: Kerscher, Marion [VerfasserIn]
• Verfasst von: Comba, Peter [VerfasserIn]
• Titel: Heteroatom‐interchanged isomers of lissoclinamide 5
• Titelzusatz: Copper(II) complexation, halide binding, and biological activity
• Verf.angabe: Sida Xie, Andrei I. Savchenko, Marion Kerscher, Rebecca L. Grange, Elizabeth H. Krenske, Jeffrey R. Harmer, Michelle J. Bauer, Natasa Broit, Dianne J. Watters, Glen M. Boyle, Paul V. Bernhardt, Peter G. Parsons, Peter Comba, Lawrence R. Gahan, and Craig M. Williams
• E-Jahr: 2018
• Jahr: 25 March 2018
• Umfang: 12 S.
• Fussnoten: Gesehen am 16.04.2020
• Titel Quelle: Enthalten in: European journal of organic chemistry
• Ort Quelle: Weinheim : Wiley-VCH Verl., 1998
• Jahr Quelle: 2018
• Band/Heft Quelle: (2018), 12, Seite 1465-1476
• ISSN Quelle: 1099-0690
• DOI: doi:10.1002/ejoc.201701659
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1694668134

Abstract

Cyclic peptides found in nature are often proposed as biological metal chelators owing to their cavitand architectures. This theory was probed by synthesizing and evaluating the physical and biological properties of heteroatom‐interchanged variants. A comprehensive study reaffirmed that small structural changes induce dramatic effects in complexation, halide binding, and biological activity.