| |  Online-Ressource |
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| Verfasst von: | Currà, Chiara [VerfasserIn]  |
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| | Kehrer, Jessica [VerfasserIn] |
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| | Lemgruber, Leandro [VerfasserIn] |
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| | Silva, Patricia A. G. C. [VerfasserIn] |
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| | Bertuccini, Lucia [VerfasserIn] |
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| | Superti, Fabiana [VerfasserIn] |
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| | Pace, Tomasino [VerfasserIn] |
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| | Ponzi, Marta [VerfasserIn] |
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| | Frischknecht, Friedrich [VerfasserIn] |
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| | Siden-Kiamos, Inga [VerfasserIn] |
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| | Mair, Gunnar R. [VerfasserIn] |
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| Titel: | Malaria transmission through the mosquito requires the function of the OMD protein |
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| Verf.angabe: | Chiara Currà, Jessica Kehrer, Leandro Lemgruber, Patricia A.G.C. Silva, Lucia Bertuccini, Fabiana Superti, Tomasino Pace, Marta Ponzi, Friedrich Frischknecht, Inga Siden-Kiamos, Gunnar R. Mair |
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| E-Jahr: | 2019 |
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| Jahr: | September 25, 2019 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 16.04.2020 |
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| Titel Quelle: | Enthalten in: OncoTarget |
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| Ort Quelle: | [Erscheinungsort nicht ermittelbar] : Impact Journals LLC, 2010 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 14(2019,9) Artikel-Nummer e0222226, 11 Seiten |
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| ISSN Quelle: | 1949-2553 |
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| Abstract: | Ookinetes, one of the motile and invasive forms of the malaria parasite, rely on gliding motility in order to establish an infection in the mosquito host. Here we characterize the protein PBANKA_0407300 which is conserved in the Plasmodium genus but lacks significant similarity to proteins of other eukaryotes. It is expressed in gametocytes and throughout the invasive mosquito stages of P. berghei, but is absent from asexual blood stages. Mutants lacking the protein developed morphologically normal ookinetes that were devoid of productive motility although some stretching movement could be detected. We therefore named the protein Ookinete Motility Deficient (OMD). Several key factors known to be involved in motility however were normally expressed and localized in the mutant. Importantly, the mutant failed to establish an infection in the mosquito which resulted in a total malaria transmission blockade. |
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| DOI: | doi:10.1371/journal.pone.0222226 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1371/journal.pone.0222226 |
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| | Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222226 |
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| | DOI: https://doi.org/10.1371/journal.pone.0222226 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Blood |
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| | Gametocytes |
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| | Malarial parasites |
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| | Oocysts |
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| | Parasitic diseases |
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| | Plasmid construction |
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| | Plasmodium |
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| | Polymerase chain reaction |
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| K10plus-PPN: | 169467908X |
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| Verknüpfungen: | → Zeitschrift |
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Malaria transmission through the mosquito requires the function of the OMD protein / Currà, Chiara [VerfasserIn]; September 25, 2019 (Online-Ressource)
