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| Verfasst von: | Roh, Vincent [VerfasserIn]  |
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| | Nowrouzi, Ali [VerfasserIn] |
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| | Abdollahi, Amir [VerfasserIn] |
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| Titel: | Cellular barcoding identifies clonal substitution as a hallmark of local recurrence in a surgical model of head and neck squamous cell carcinoma |
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| Verf.angabe: | Vincent Roh, Pierre Abramowski, Agnès Hiou-Feige, Kerstin Cornils, Jean-Paul Rivals, Alexandre Zougman, Tim Aranyossy, Lars Thielecke, Zinnia Truan, Maxime Mermod, Yan Monnier, Vladimir Prassolov, Ingmar Glauche, Ali Nowrouzi, Amir Abdollahi, Boris Fehse, Christian Simon, Genrich V. Tolstonog |
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| E-Jahr: | 2018 |
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| Jahr: | November 20, 2018 |
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| Umfang: | 23 S. |
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| Fussnoten: | Gesehen am 16.04.2020 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 25(2018), 8, Seite 2208-2222,e1-e7 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with a dismal prognosis. Improving this outcome requires a better understanding of cancer cell populations that expand from postsurgical minimal residual disease (MRD). Therefore, we assessed clonal dynamics in a surgical model of barcoded HNSCC growing in the submental region of immunodeficient mice. Clonal substitution and massive reduction of clonal heterogeneity emerged as hallmarks of local recurrence, as the clones dominating in less heterogeneous recurrences were scarce in their matched primary tumors. These lineages were selected by their ability to persist after surgery and competitively expand from MRD. Clones enriched in recurrences exhibited both private and shared genetic features and likely originated from ancestors shared with clones dominating in primary tumors. They demonstrated high invasiveness and epithelial-to-mesenchymal transition, eventually providing an attractive target for obtaining better local control for these tumors. |
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| DOI: | doi:10.1016/j.celrep.2018.10.090 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.celrep.2018.10.090 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2211124718316942 |
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| | DOI: https://doi.org/10.1016/j.celrep.2018.10.090 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | clonal heterogeneity |
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| | clonal substitution |
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| | DNA barcoding |
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| | epithelial-mesenchymal transition |
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| | head and neck squamous cell carcinoma |
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| | invasion |
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| | LeGO vectors |
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| | recurrent tumor-initiating clones |
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| | RGB marking |
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| K10plus-PPN: | 1694685306 |
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| Verknüpfungen: | → Zeitschrift |
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Cellular barcoding identifies clonal substitution as a hallmark of local recurrence in a surgical model of head and neck squamous cell carcinoma / Roh, Vincent [VerfasserIn]; November 20, 2018 (Online-Ressource)
