| |  Online-Ressource |
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| Verfasst von: | Rojas, Teresa de [VerfasserIn]  |
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| | Kasper, Bernd [VerfasserIn] |
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| | Graaf, Wilhelmina Tita Alide van der [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Bielle, Franck [VerfasserIn] |
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| | Ribalta, Teresa [VerfasserIn] |
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| | Shenjere, Patrick [VerfasserIn] |
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| | Preusser, Matthias [VerfasserIn] |
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| | Fröhling, Stefan [VerfasserIn] |
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| | Golfinopoulos, Vassilis [VerfasserIn] |
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| | Morfouace, Marie [VerfasserIn] |
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| | McCabe, Martin G. [VerfasserIn] |
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| Titel: | EORTC SPECTA-AYA |
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| Titelzusatz: | a unique molecular profiling platform for adolescents and young adults with cancer in Europe |
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| Verf.angabe: | Teresa de Rojas, Bernd Kasper, Winette Van der Graaf, Stefan M. Pfister, Franck Bielle, Teresa Ribalta, Patrick Shenjere, Matthias Preusser, Stefan Fröhling, Vassilis Golfinopoulos, Marie Morfouace, Martin G. McCabe |
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| E-Jahr: | 2019 |
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| Jahr: | 29 August 2019 |
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| Fussnoten: | Gesehen am 16.04.2020 |
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| Titel Quelle: | Enthalten in: International journal of cancer |
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| Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 147(2020), 4, Seite 1180-1184 |
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| ISSN Quelle: | 1097-0215 |
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| Abstract: | For most adolescent and young adult (AYA) cancers, age-specific molecular features are poorly understood. EORTC-SPECTA, an academic translational research infrastructure for biomaterial collection, will explicitly recruit AYA patients and will therefore collect empirical data to bridge the molecular gap between pediatric and adult oncology. The initial pilot study, activated in February 2019 across Europe, will recruit 100 AYA patients (aged 12-29 years) with newly diagnosed or relapsed high-grade gliomas and high-grade bone and soft tissue sarcomas. The primary objective of the pilot is to determine feasibility and recruitment rates. Formalin-fixed tumor tissue and whole blood from study participants will be prospectively collected with clinical data and stored centrally at the Integrated BioBank of Luxembourg. Whole exome sequencing of matched tumor and blood, and tumor RNA sequencing and DNA methylation profiling will be performed at the German Cancer Research Center, Heidelberg, Germany. Virtual central pathology review of scanned diagnostic slides will be undertaken by an international expert panel, and diagnostic material returned to the participating centers. A multidisciplinary molecular tumor board will release a clinically validated report to referring clinicians within 4-6 weeks after biopsy. SPECTA-AYA constitutes a major opportunity to gain knowledge about the tumor biology of this unique age group. It incorporates notable innovative aspects: AYA specificity, pan-European academic collaboration, centralized biobanking, comprehensive molecular profiling and virtual central pathology review, among others. SPECTA-AYA will help untangle the tumor particularities of AYAs with cancer and aims to improve their access to novel drugs and personalized medicine. |
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| DOI: | doi:10.1002/ijc.32651 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/ijc.32651 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32651 |
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| | DOI: https://doi.org/10.1002/ijc.32651 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adolescents and young adults |
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| | high grade glioma |
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| | molecular profiling |
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| | personalized medicine |
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| | sarcoma |
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| K10plus-PPN: | 1694699110 |
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| Verknüpfungen: | → Zeitschrift |
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EORTC SPECTA-AYA / Rojas, Teresa de [VerfasserIn]; 29 August 2019 (Online-Ressource)
