α-Imino gold carbene intermediates from readily accessible sulfilimines

• Verfasst von: Tian, Xianhai [VerfasserIn]
• Verfasst von: Song, Lina [VerfasserIn]
• Verfasst von: Hashmi, A. Stephen K. [VerfasserIn]
• Titel: α-Imino gold carbene intermediates from readily accessible sulfilimines
• Titelzusatz: intermolecular access to structural diversity
• Verf.angabe: Xianhai Tian, Lina Song, and A. Stephen K. Hashmi
• Jahr: 2020
• Umfang: 8 S.
• Teil: volume:26
• Teil: year:2020
• Teil: number:15
• Teil: pages:3197-3204
• Teil: extent:8
• Fussnoten: First published: 03 December 2019 ; Im Text wird alpha als griechisches Zeichen dargestellt ; Gesehen am 16.04.2020
• Titel Quelle: Enthalten in: Chemistry - a European journal
• Ort Quelle: Weinheim : Wiley-VCH, 1995
• Jahr Quelle: 2020
• Band/Heft Quelle: 26(2020), 15, Seite 3197-3204
• ISSN Quelle: 1521-3765
• DOI: doi:10.1002/chem.201904869
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: heterocycles
• Sach-SW: nitrene transfer
• Sach-SW: sulfilimines
• Sach-SW: sulfur ylides
• Sach-SW: α-imino gold carbenes
• K10plus-PPN: 1694725782
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Abstract Catalytic approaches to pharmaceutically important bioactive skeletons through gold carbene intermediates have experienced a dramatic development in the last decade. Although various carbene precursors continue to play an important role in heterocyclic syntheses, these reagents are associated with some drawbacks in terms of functional group tolerance, synthetic methods and safety limitations. A new generation of nitrene transfer reagents was established in 2019: the sulfilimines. These are safe, inexpensive and readily available. They can conveniently be stored and handled, and thus represent ideal reagents for the fast and modular modification of scaffolds and the preparation of libraries by intermolecular reactions of two components. Both the practical methods for synthesizing sulfilimines and the versatility of these ylidic species in gold-catalyzed preparation of structural diversity, for both heterocycles and carbocycles, will be outlined in this Concept article.