Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

• Verfasst von: Montgomery, Samuel T. [VerfasserIn]
• Verfasst von: Dittrich, A. Susanne [VerfasserIn]
• Verfasst von: Frey, Dario [VerfasserIn]
• Verfasst von: Mall, Marcus A. [VerfasserIn]
• Titel: Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis
• Verf.angabe: Samuel T. Montgomery, A. Susanne Dittrich, Luke W. Garratt, Lidija Turkovic, Dario L. Frey, Stephen M. Stick, Marcus A. Mall, Anthony Kicic
• E-Jahr: 2018
• Jahr: 6 June 2018
• Umfang: 8 S.
• Fussnoten: Gesehen am 16.04.2020
• Titel Quelle: Enthalten in: Journal of cystic fibrosis
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 2002
• Jahr Quelle: 2018
• Band/Heft Quelle: 17(2018), 6, Seite 715-722
• ISSN Quelle: 1873-5010
• DOI: doi:10.1016/j.jcf.2018.05.006
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Airway epithelium
• Sach-SW: Cystic fibrosis
• Sach-SW: Hypoxia
• Sach-SW: Interleukin (IL)-1
• Sach-SW: Mucus
• Sach-SW: Neutrophilic inflammation
• K10plus-PPN: 1694741362

Abstract

Background - Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF. - Methods - Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α, IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to structural lung changes observed on chest computed tomography (CT) scans. - Results - IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p<0.0001), neutrophils (p<0.0001) and NE activity (p<0.01 and p<0.001). IL-1α had the strongest association with structural lung disease (p <0.01) in the absence of infection (uninfected: p<0.01 vs. infected: p=0.122). - Conclusion - Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target.