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Verfasst von:Westhauser, Fabian [VerfasserIn]   i
 Hohenbild, Frederike [VerfasserIn]   i
 Arango-Ospina, Marcela [VerfasserIn]   i
 Schmitz, Sarah I. [VerfasserIn]   i
 Wilkesmann, Sebastian [VerfasserIn]   i
 Hupa, Leena [VerfasserIn]   i
 Moghaddam-Alvandi, Arash [VerfasserIn]   i
 Boccaccini, Aldo R. [VerfasserIn]   i
Titel:Bioactive glass (BG) ICIE16 shows promising osteogenic properties compared to crystallized 45S5-BG
Verf.angabe:Fabian Westhauser, Frederike Hohenbild, Marcela Arango-Ospina, Sarah I. Schmitz, Sebastian Wilkesmann, Leena Hupa, Arash Moghaddam and Aldo R. Boccaccini
E-Jahr:2020
Jahr:28 February 2020
Umfang:12 S.
Fussnoten:Gesehen am 16.04.2020
Titel Quelle:Enthalten in: International journal of molecular sciences
Ort Quelle:Basel : Molecular Diversity Preservation International, 2000
Jahr Quelle:2020
Band/Heft Quelle:21(2020,5) Artikel-Nummer 1639, 12 Seiten
ISSN Quelle:1422-0067
 1661-6596
Abstract:The ICIE16-bioactive glass (BG) (48.0 SiO2, 6.6 Na2O, 32.9 CaO, 2.5 P2O5, 10.0 K2O (wt %)) has been developed as an alternative to 45S5-BG, the original BG composition (45.0 SiO2, 24.5 Na2O, 24.5 CaO, 6.0 P2O5 (wt %)), with the intention of broadening the BG sintering window while maintaining bioactivity. Because there is a lack of reports on ICIE16-BG biological properties, the influence of ICIE16-BG on viability, proliferation, and osteogenic differentiation of human mesenchymal stromal cells (MSCs) was evaluated in direct comparison to 45S5-BG in this study. The BGs underwent heat treatment similar to that which is required in order to fabricate scaffolds by sintering, which resulted in crystallization of 45S5-BG (45S5-CBG) while ICIE16 remained amorphous. Granules based on both BGs were biocompatible, but ICIE16-BG was less harmful to cell viability, most likely due to a more pronounced pH alkalization in the 45S5-CBG group. ICIE16-BG outperformed 45S5-CBG in terms of osteogenic differentiation at the cellular level, as determined by the increased activity of alkaline phosphatase. However, granules from both BGs were comparable regarding the stimulation of expression levels of genes encoding for osseous extracellular matrix (ECM) proteins. The addition of therapeutically active ions to ICIE16-BG might further improve its ability to stimulate ECM production and should be investigated in upcoming studies.
DOI:doi:10.3390/ijms21051639
URL:kostenfrei: Volltext: https://doi.org/10.3390/ijms21051639
 kostenfrei: Volltext: https://www.mdpi.com/1422-0067/21/5/1639
 DOI: https://doi.org/10.3390/ijms21051639
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:45S5 bioactive glass
 human mesenchymal stromal cells
 ICIE16 bioactive glass
 osteogenic differentiation
 proliferation
K10plus-PPN:1694793834
Verknüpfungen:→ Zeitschrift
 
 
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