| |  Online-Ressource |
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| Verfasst von: | Uhl, Philipp [VerfasserIn]  |
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| | Sauter, Max [VerfasserIn] |
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| | Storck, Philip [VerfasserIn] |
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| | Tursch, Anja [VerfasserIn] |
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| | Özbek, Suat [VerfasserIn] |
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| | Leotta, Karin [VerfasserIn] |
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| | Fidelj, Veronika [VerfasserIn] |
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| | Kleist, Christian [VerfasserIn] |
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| | Fricker, Gert [VerfasserIn] |
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| | Mier, Walter [VerfasserIn] |
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| Titel: | Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide |
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| Verf.angabe: | P. Uhl, PhD, C.Grundmann, M. Sauter, PhD, P. Storck, A. Tursch, S. Özbek, Prof, PhD, K. Leotta, R. Roth, PhD, D. Witzigmann, PhD, J.A. Kulkarnie, V. Fidelj, C. Kleist, PhD, P.R. Cullis, Prof, PhD, G. Fricker, Prof, PhD, W. Mier, Prof, PhD |
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| Jahr: | 2020 |
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| Umfang: | 10 S. |
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| Teil: | volume:24 |
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| | year:2020 |
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| | extent:10 |
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| Fussnoten: | Available online 27 November 2019 ; Gesehen am 17.04.2020 |
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| Titel Quelle: | Enthalten in: Nanomedicine / Nanotechnology, biology and medicine |
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| Ort Quelle: | New York, NY : Elsevier, 2005 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 24(2020) Artikel-Nummer 102132, 10 Seiten |
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| ISSN Quelle: | 1549-9642 |
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| Abstract: | Until today, the oral delivery of peptide drugs is hampered due to their instability in the gastrointestinal tract and low mucosal penetration. To overcome these hurdles, PLA (polylactide acid)-nanoparticles were coated with a cyclic, polyarginine-rich, cell penetrating peptide (cyclic R9-CPP). These surface-modified nanoparticles showed a size and polydispersity index comparable to standard PLA-nanoparticles. The zeta potential showed a significant increase indicating successful CPP-coupling to the surface of the nanoparticles. Cryo-EM micrographs confirmed the appropriate size and morphology of the modified nanoparticles. A high encapsulation efficiency of liraglutide could be achieved. In vitro tests using Caco-2 cells showed high viability indicating the tolerability of this novel formulation. A strongly enhanced mucosal binding and penetration was demonstrated by a Caco-2 binding and uptake assay. In Wistar rats, the novel nanoparticles showed a substantial, 4.5-fold increase in the oral bioavailability of liraglutide revealing great potential for the oral delivery of peptide drugs. |
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| DOI: | doi:10.1016/j.nano.2019.102132 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.nano.2019.102132 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1549963419302163 |
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| | DOI: https://doi.org/10.1016/j.nano.2019.102132 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cell penetrating peptides |
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| | Liraglutide |
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| | Nanoparticles |
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| | Oral delivery |
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| | Peptide drugs |
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| | Polylactide acid |
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| K10plus-PPN: | 1694852857 |
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| Verknüpfungen: | → Zeitschrift |
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Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide / Uhl, Philipp [VerfasserIn]; 2020 (Online-Ressource)
