Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Hall, Amy L. [VerfasserIn]   i
 Ramroth, Heribert [VerfasserIn]   i
 Ahrens, Wolfgang [VerfasserIn]   i
Titel:Laryngeal cancer risks in workers exposed to lung carcinogens
Titelzusatz:exposure-effect analyses using a quantitative job exposure matrix
Verf.angabe:Amy L. Hall, Hans Kromhout, Joachim Schüz, Susan Peters, Lützen Portengen, Roel Vermeulen, Antonio Agudo, Wolfgang Ahrens, Paolo Boffetta, Paul Brennan, Cristina Canova, David I. Conway, Maria Paula Curado, Alexander W. Daudt, Leticia Fernandez, Mia Hashibe, Claire M. Healy, Ivana Holcatova, Kristina Kjaerheim, Rosalina Koifman, Pagona Lagiou, Danièle Luce, Gary J. Macfarlane, Ana Menezes, Gwenn Menvielle, Jerry Polesel, Heribert Ramroth, Lorenzo Richiardi, Isabelle Stücker, Peter Thomson, Marta Vilensky, Victor Wunsch-Filho, Amy Lee Yuan-Chin, Ariana Znaor, Kurt Straif, Ann Olsson
E-Jahr:2020
Jahr:January 2020
Umfang:10 S.
Fussnoten:Gesehen am 20.04.2020
Titel Quelle:Enthalten in: Epidemiology
Ort Quelle:Baltimore, Md. : Wolters Kluwer Health, Lippincott Williams & Wilkins, 1990
Jahr Quelle:2020
Band/Heft Quelle:31(2020), 1, Seite 145-154
ISSN Quelle:1531-5487
Abstract:Introduction: - Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders. - Methods: - This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the International Head and Neck Cancer Epidemiology Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989 to 2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined) and females (asbestos and respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant. - Results: - Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, P values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI and nickel combined); strongest associations were for asbestos at >90th percentile cumulative exposure (OR = 1.3, 95% confidence interval [CI] = 1.0, 1.6), respirable crystalline silica at 30+ years duration (OR = 1.4, 95% CI = 1.2, 1.7) and 75th-90th percentile cumulative exposure (OR = 1.4, 95% CI = 1.1, 1.8), chromium-VI at >75th percentile cumulative exposure (OR = 1.9, 95% CI = 1.2, 3.0), and chromium-VI and nickel combined at 20-29 years duration (OR = 1.5, 95% CI = 1.1, 2.2). - Conclusions: - These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.
DOI:doi:10.1097/EDE.0000000000001120
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/EDE.0000000000001120
 Volltext: https://journals.lww.com/epidem/Abstract/2020/01000/Laryngeal_Cancer_Risks_in_Workers_Exposed_to_Lung.17.aspx
 DOI: https://doi.org/10.1097/EDE.0000000000001120
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1694944980
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68567965   QR-Code
zum Seitenanfang