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Status: Bibliographieeintrag

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Verfasst von:Liu, Tengfei [VerfasserIn]   i
 Riabov, Vladimir [VerfasserIn]   i
 Klüter, Harald [VerfasserIn]   i
 Kzhyshkowska, Julia [VerfasserIn]   i
Titel:Tumor-associated macrophages in human breast cancer produce new monocyte attracting and pro-angiogenic factor YKL-39 indicative for increased metastasis after neoadjuvant chemotherapy
Verf.angabe:Tengfei Liu, Irina Larionova, Nikolay Litviakov, Vladimir Riabov, Marina Zavyalova, Matvey Tsyganov, Mikhail Buldakov, Bin Song, Kondaiah Moganti, Polina Kazantseva, Elena Slonimskaya, Elisabeth Kremmer, Andrew Flatley, Harald Klüter, Nadezhda Cherdyntseva, and Julia Kzhyshkowska
E-Jahr:2018
Jahr:13 Mar 2018
Umfang:17 S.
Fussnoten:Gesehen am 20.04.2020
Titel Quelle:Enthalten in: OncoImmunology
Ort Quelle:Abingdon : Taylor & Franics, 2012
Jahr Quelle:2018
Band/Heft Quelle:7(2018,6) Artikel-Nummer e1436922, 17 Seiten
ISSN Quelle:2162-402X
Abstract:In breast cancer, the tumor microenvironment plays a critical role in the tumor progression and responses to therapy. Tumor-associated macrophages (TAMs) are major innate immune cells in tumor microenvironment that regulate intratumoral immunity and angiogenesis by secretion of cytokines, growth factors as well as chitinase-like proteins (CLPs), that combine properties of cytokines and growth factors. YKL-39 is a chitinase-like protein found in human and absent in rodents, and its expression in TAMs and role in breast cancer progression was not studied to date. Here for the first time we demonstrate that YKL-39 is expressed on TAMs, predominantly positive for stabilin-1, but not by malignant cells or other stromal cells in human breast cancer. TGF-beta in combination with IL-4, but not IL-4 alone was responsible of the stimulation of the production of YKL-39 in human primary macrophages. Mechanistically, stabilin-1 directly interacted with YKL-39 and acted as sorting receptor for targeting YKL-39 into the secretory pathway. Functionally, purified YKL-39 acted as a strong chemotactic factor for primary human monocytes, and induced angiogenesis in vitro. Elevated levels of YKL-39 expression in tumors after neoadjuvant chemotherapy (NAC) were predictive for increased risk of distant metastasis and for poor response to NAC in patients with nonspecific invasive breast carcinoma. Our findings suggest YKL-39 as a novel therapeutic target, and blocking of its activity can be combined with NAC in order to reduce the risk of metastasis in breast cancer patients.
DOI:doi:10.1080/2162402X.2018.1436922
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1080/2162402X.2018.1436922
 DOI: https://doi.org/10.1080/2162402X.2018.1436922
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:angiogenesis
 breast cancer
 chemotaxis
 chitinase-like protein
 monocyte
 neoadjuvant chemotherapy
 tumor-associated macrophage
 YKL-39
K10plus-PPN:1694959295
Verknüpfungen:→ Zeitschrift

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