Status: Bibliographieeintrag
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| Verfasst von: | Viarisio, Daniele [VerfasserIn]  |
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| | Robitaille, Alexis [VerfasserIn] |
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| | Müller-Decker, Karin [VerfasserIn] |
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| | Flechtenmacher, Christa [VerfasserIn] |
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| | Gissmann, Lutz [VerfasserIn] |
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| | Tommasino, Massimo [VerfasserIn] |
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| Titel: | Cancer susceptibility of beta HPV49 E6 and E7 transgenic mice to 4-nitroquinoline 1-oxide treatment correlates with mutational signatures of tobacco exposure |
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| Verf.angabe: | Daniele Viarisio, Alexis Robitaille, Karin Müller-Decker, Christa Flechtenmacher, Lutz Gissmann, Massimo Tommasino |
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| E-Jahr: | 2019 |
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| Jahr: | 24 September 2019 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 20.04.2020 |
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| Titel Quelle: | Enthalten in: Virology |
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| Ort Quelle: | San Diego, Calif. [u.a.] : Elsevier, 1955 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 538(2019), Seite 53-60 |
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| ISSN Quelle: | 1096-0341 |
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| Abstract: | We have previously showed that a transgenic (Tg) mouse model with cytokeratin 14 promoter (K14)-driven expression of E6 and E7 from beta-3 HPV49 in the basal layer of the epidermis and of the mucosal epithelia of the digestive tract (K14 HPV49 E6/E7 Tg mice) are highly susceptible to upper digestive tract carcinogenesis upon exposure to 4-nitroquinoline 1-oxide (4NQO). Using whole-exome sequencing, we show that in K14 HPV49 E6/E7 Tg mice, development of 4NQO-induced cancers tightly correlates with the accumulation of somatic mutations in cancer-related genes. The mutational signature in 4NQO-treated mice was similar to the signature observed in humans exposed to tobacco smoking and tobacco chewing. Similar results were obtained with K14 Tg animals expressing mucosal high-risk HPV16 E6 and E7 oncogenes. Thus, beta-3 HPV49 share some functional similarities with HPV16 in Tg animals. |
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| DOI: | doi:10.1016/j.virol.2019.09.010 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.virol.2019.09.010 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0042682219302752 |
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| | DOI: https://doi.org/10.1016/j.virol.2019.09.010 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 4-Nitroquinoline 1-oxide |
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| | Beta HPV types |
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| | Mutational signatures of tobacco exposure |
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| | Upper-digestive tract cancer |
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| K10plus-PPN: | 1695025261 |
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| Verknüpfungen: | → Zeitschrift |
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Cancer susceptibility of beta HPV49 E6 and E7 transgenic mice to 4-nitroquinoline 1-oxide treatment correlates with mutational signatures of tobacco exposure / Viarisio, Daniele [VerfasserIn]; 24 September 2019 (Online-Ressource)
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