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Status: Bibliographieeintrag

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Verfasst von:Stiermaier, Thomas [VerfasserIn]   i
 Santoro, Francesco [VerfasserIn]   i
 El-Battrawy, Ibrahim [VerfasserIn]   i
 Möller, Christian [VerfasserIn]   i
 Graf, Tobias [VerfasserIn]   i
 Novo, Giuseppina [VerfasserIn]   i
 Santangelo, Andrea [VerfasserIn]   i
 Mariano, Enrica [VerfasserIn]   i
 Romeo, Francesco [VerfasserIn]   i
 Caldarola, Pasquale [VerfasserIn]   i
 Fanelli, Mario [VerfasserIn]   i
 Thiele, Holger [VerfasserIn]   i
 Brunetti, Natale Daniele [VerfasserIn]   i
 Akın, Ibrahim [VerfasserIn]   i
 Eitel, Ingo [VerfasserIn]   i
Titel:Prevalence and prognostic impact of diabetes in takotsubo syndrome
Titelzusatz:insights from the international, multicenter GEIST registry
Verf.angabe:Thomas Stiermaier, Francesco Santoro, Ibrahim El-Battrawy, Christian Möller, Tobias Graf, Giuseppina Novo, Andrea Santangelo, Enrica Mariano, Francesco Romeo, Pasquale Caldarola, Mario Fanelli, Holger Thiele, Natale Daniele Brunetti, Ibrahim Akin and Ingo Eitel
Jahr:2018
Umfang:5 S.
Fussnoten:Gesehen am 21.04.2020
Titel Quelle:Enthalten in: Diabetes care
Ort Quelle:Alexandria, Va. : Assoc., 1978
Jahr Quelle:2018
Band/Heft Quelle:41(2018), 5, Seite 1084-1088
ISSN Quelle:1935-5548
Abstract:OBJECTIVE: In view of low prevalence rates, diabetes is discussed as a protective factor for the occurrence of Takotsubo syndrome (TTS). Furthermore, it was associated with improved outcome in a small single-center analysis. Therefore, this study assessed the prevalence and prognostic relevance of concomitant diabetes in TTS. - RESEARCH DESIGN AND METHODS: A total of 826 patients with TTS were enrolled in an international, multicenter, registry-based study (eight centers in Italy and Germany). All-cause mortality was compared between patients with diabetes and patients without diabetes, and the independent predictive value of diabetes was evaluated in multivariate regression analysis. - RESULTS: The prevalence of diabetes was 21.1% (n = 174). TTS patients with diabetes were older (P < 0.001), were more frequently male (P = 0.003), had a higher prevalence of hypertension (P < 0.001), physical triggers (P = 0.041), and typical apical ballooning (P = 0.010), had a lower left ventricular ejection fraction (P = 0.008), had a higher rate of pulmonary edema (P = 0.032), and had a longer hospital stay (P = 0.009). However, 28-day all-cause mortality did not differ between patients with diabetes and patients without diabetes (6.4% vs. 5.7%; hazard ratio [HR] 1.11 [95% CI 0.55-2.25]; P = 0.772). Longer-term follow-up after a median of 2.5 years revealed a significantly higher mortality among TTS patients with diabetes (31.4% vs. 16.5%; P < 0.001), and multivariate regression analysis identified diabetes as an independent predictor of adverse outcome (HR 1.66 [95% CI 1.16-2.39]; P = 0.006). - CONCLUSIONS: Diabetes is not uncommon in patients with TTS, is associated with increased longer-term mortality rates, and is an independent predictor of adverse outcome irrespective of additional risk factors.
DOI:doi:10.2337/dc17-2609
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.2337/dc17-2609
 Volltext: https://care.diabetesjournals.org/content/41/5/1084.long
 DOI: https://doi.org/10.2337/dc17-2609
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aged
 Diabetes Mellitus
 Diabetic Cardiomyopathies
 Female
 Germany
 Humans
 Italy
 Male
 Middle Aged
 Prevalence
 Prognosis
 Registries
 Risk Factors
 Takotsubo Cardiomyopathy
K10plus-PPN:1695253884
Verknüpfungen:→ Zeitschrift

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