| Online-Ressource |
Verfasst von: | Stiermaier, Thomas [VerfasserIn]  |
| Santoro, Francesco [VerfasserIn]  |
| El-Battrawy, Ibrahim [VerfasserIn]  |
| Möller, Christian [VerfasserIn]  |
| Graf, Tobias [VerfasserIn]  |
| Novo, Giuseppina [VerfasserIn]  |
| Santangelo, Andrea [VerfasserIn]  |
| Mariano, Enrica [VerfasserIn]  |
| Romeo, Francesco [VerfasserIn]  |
| Caldarola, Pasquale [VerfasserIn]  |
| Fanelli, Mario [VerfasserIn]  |
| Thiele, Holger [VerfasserIn]  |
| Brunetti, Natale Daniele [VerfasserIn]  |
| Akın, Ibrahim [VerfasserIn]  |
| Eitel, Ingo [VerfasserIn]  |
Titel: | Prevalence and prognostic impact of diabetes in takotsubo syndrome |
Titelzusatz: | insights from the international, multicenter GEIST registry |
Verf.angabe: | Thomas Stiermaier, Francesco Santoro, Ibrahim El-Battrawy, Christian Möller, Tobias Graf, Giuseppina Novo, Andrea Santangelo, Enrica Mariano, Francesco Romeo, Pasquale Caldarola, Mario Fanelli, Holger Thiele, Natale Daniele Brunetti, Ibrahim Akin and Ingo Eitel |
Jahr: | 2018 |
Umfang: | 5 S. |
Fussnoten: | Gesehen am 21.04.2020 |
Titel Quelle: | Enthalten in: Diabetes care |
Ort Quelle: | Alexandria, Va. : Assoc., 1978 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 41(2018), 5, Seite 1084-1088 |
ISSN Quelle: | 1935-5548 |
Abstract: | OBJECTIVE: In view of low prevalence rates, diabetes is discussed as a protective factor for the occurrence of Takotsubo syndrome (TTS). Furthermore, it was associated with improved outcome in a small single-center analysis. Therefore, this study assessed the prevalence and prognostic relevance of concomitant diabetes in TTS. - RESEARCH DESIGN AND METHODS: A total of 826 patients with TTS were enrolled in an international, multicenter, registry-based study (eight centers in Italy and Germany). All-cause mortality was compared between patients with diabetes and patients without diabetes, and the independent predictive value of diabetes was evaluated in multivariate regression analysis. - RESULTS: The prevalence of diabetes was 21.1% (n = 174). TTS patients with diabetes were older (P < 0.001), were more frequently male (P = 0.003), had a higher prevalence of hypertension (P < 0.001), physical triggers (P = 0.041), and typical apical ballooning (P = 0.010), had a lower left ventricular ejection fraction (P = 0.008), had a higher rate of pulmonary edema (P = 0.032), and had a longer hospital stay (P = 0.009). However, 28-day all-cause mortality did not differ between patients with diabetes and patients without diabetes (6.4% vs. 5.7%; hazard ratio [HR] 1.11 [95% CI 0.55-2.25]; P = 0.772). Longer-term follow-up after a median of 2.5 years revealed a significantly higher mortality among TTS patients with diabetes (31.4% vs. 16.5%; P < 0.001), and multivariate regression analysis identified diabetes as an independent predictor of adverse outcome (HR 1.66 [95% CI 1.16-2.39]; P = 0.006). - CONCLUSIONS: Diabetes is not uncommon in patients with TTS, is associated with increased longer-term mortality rates, and is an independent predictor of adverse outcome irrespective of additional risk factors. |
DOI: | doi:10.2337/dc17-2609 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.2337/dc17-2609 |
| Volltext: https://care.diabetesjournals.org/content/41/5/1084.long |
| DOI: https://doi.org/10.2337/dc17-2609 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Aged |
| Diabetes Mellitus |
| Diabetic Cardiomyopathies |
| Female |
| Germany |
| Humans |
| Italy |
| Male |
| Middle Aged |
| Prevalence |
| Prognosis |
| Registries |
| Risk Factors |
| Takotsubo Cardiomyopathy |
K10plus-PPN: | 1695253884 |
Verknüpfungen: | → Zeitschrift |
Prevalence and prognostic impact of diabetes in takotsubo syndrome / Stiermaier, Thomas [VerfasserIn]; 2018 (Online-Ressource)