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Verfasst von:Stace, Rebecca E. A. [VerfasserIn]   i
 Stiehl, Thomas [VerfasserIn]   i
 Chaplain, Mark A. J. [VerfasserIn]   i
 Marciniak-Czochra, Anna [VerfasserIn]   i
 Lorenzi, Tommaso [VerfasserIn]   i
Titel:Discrete and continuum phenotype-structured models for the evolution of cancer cell populations under chemotherapy
Verf.angabe:Rebecca E.A. Stace, Thomas Stiehl, Mark A.J. Chaplain, Anna Marciniak-Czochra and Tommaso Lorenzi
E-Jahr:2020
Jahr:12 March 2020
Umfang:22 S.
Fussnoten:Gesehen am 21.04.2020
Titel Quelle:Enthalten in: Mathematical modelling of natural phenomena
Ort Quelle:Les Ulis : EDP Sciences, 2006
Jahr Quelle:2020
Band/Heft Quelle:15(2020) Artikel-Nummer 14, 22 Seiten
ISSN Quelle:1760-6101
Abstract:We present a stochastic individual-based model for the phenotypic evolution of cancer cell populations under chemotherapy. In particular, we consider the case of combination cancer therapy whereby a chemotherapeutic agent is administered as the primary treatment and an epigenetic drug is used as an adjuvant treatment. The cell population is structured by the expression level of a gene that controls cell proliferation and chemoresistance. In order to obtain an analytical description of evolutionary dynamics, we formally derive a deterministic continuum counterpart of this discrete model, which is given by a nonlocal parabolic equation for the cell population density function. Integrating computational simulations of the individual-based model with analysis of the corresponding continuum model, we perform a complete exploration of the model parameter space. We show that harsher environmental conditions and higher probabilities of spontaneous epimutation can lead to more effective chemotherapy, and we demonstrate the existence of an inverse relationship between the efficacy of the epigenetic drug and the probability of spontaneous epimutation. Taken together, the outcomes of the model provide theoretical ground for the development of anticancer protocols that use lower concentrations of chemotherapeutic agents in combination with epigenetic drugs capable of promoting the re-expression of epigenetically regulated genes.
DOI:doi:10.1051/mmnp/2019027
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1051/mmnp/2019027
 Volltext: https://www.mmnp-journal.org/articles/mmnp/abs/2020/01/mmnp190018/mmnp190018.html
 DOI: https://doi.org/10.1051/mmnp/2019027
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1695263855
Verknüpfungen:→ Zeitschrift

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