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Verfasst von:Tain, Luke S. [VerfasserIn]   i
 Sehlke, Robert [VerfasserIn]   i
 Jain, Chirag [VerfasserIn]   i
 Chokkalingam, Manopriya [VerfasserIn]   i
 Nagaraj, Nagarjuna [VerfasserIn]   i
 Essers, Paul [VerfasserIn]   i
 Rassner, Mark [VerfasserIn]   i
 Grönke, Sebastian [VerfasserIn]   i
 Froelich, Jenny [VerfasserIn]   i
 Dieterich, Christoph [VerfasserIn]   i
 Mann, Matthias [VerfasserIn]   i
 Alic, Nazif [VerfasserIn]   i
 Beyer, Andreas [VerfasserIn]   i
 Partridge, Linda [VerfasserIn]   i
Titel:A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance
Verf.angabe:Luke S Tain, Robert Sehlke, Chirag Jain, Manopriya Chokkalingam, Nagarjuna Nagaraj, Paul Essers, Mark Rassner, Sebastian Grönke, Jenny Froelich, Christoph Dieterich, Matthias Mann, Nazif Alic, Andreas Beyer, Linda Partridge
E-Jahr:2017
Jahr:15 September 2017
Umfang:19 S.
Fussnoten:Gesehen am 21.04.2020
Titel Quelle:Enthalten in: Molecular systems biology
Ort Quelle:[London] : Nature Publishing Group UK, 2005
Jahr Quelle:2017
Band/Heft Quelle:13(2017,9) Artikel-Nummer 939, 19 Seiten
ISSN Quelle:1744-4292
Abstract:Abstract Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long-lived IIS mutants has been extensively documented, the causal mechanisms contributing to extended lifespan, particularly in specific tissues, remain unclear. We have characterized the proteomes of four key insulin-sensitive tissues in a long-lived Drosophila IIS mutant and control, and detected 44% of the predicted proteome (6,085 proteins). Expression of ribosome-associated proteins in the fat body was reduced in the mutant, with a corresponding, tissue-specific reduction in translation. Expression of mitochondrial electron transport chain proteins in fat body was increased, leading to increased respiration, which was necessary for IIS-mediated lifespan extension, and alone sufficient to mediate it. Proteasomal subunits showed altered expression in IIS mutant gut, and gut-specific over-expression of the RPN6 proteasomal subunit, was sufficient to increase proteasomal activity and extend lifespan, whilst inhibition of proteasome activity abolished IIS-mediated longevity. Our study thus uncovered strikingly tissue-specific responses of cellular processes to lowered IIS acting in concert to ameliorate ageing.
DOI:doi:10.15252/msb.20177663
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.15252/msb.20177663
 Volltext: https://www.embopress.org/doi/full/10.15252/msb.20177663
 DOI: https://doi.org/10.15252/msb.20177663
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:ageing
 insulin/IGF
 mitochondria
 proteasome
 proteome
K10plus-PPN:1695282310
Verknüpfungen:→ Zeitschrift

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