| Online-Ressource |
Verfasst von: | Tain, Luke S. [VerfasserIn]  |
| Sehlke, Robert [VerfasserIn]  |
| Jain, Chirag [VerfasserIn]  |
| Chokkalingam, Manopriya [VerfasserIn]  |
| Nagaraj, Nagarjuna [VerfasserIn]  |
| Essers, Paul [VerfasserIn]  |
| Rassner, Mark [VerfasserIn]  |
| Grönke, Sebastian [VerfasserIn]  |
| Froelich, Jenny [VerfasserIn]  |
| Dieterich, Christoph [VerfasserIn]  |
| Mann, Matthias [VerfasserIn]  |
| Alic, Nazif [VerfasserIn]  |
| Beyer, Andreas [VerfasserIn]  |
| Partridge, Linda [VerfasserIn]  |
Titel: | A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance |
Verf.angabe: | Luke S Tain, Robert Sehlke, Chirag Jain, Manopriya Chokkalingam, Nagarjuna Nagaraj, Paul Essers, Mark Rassner, Sebastian Grönke, Jenny Froelich, Christoph Dieterich, Matthias Mann, Nazif Alic, Andreas Beyer, Linda Partridge |
E-Jahr: | 2017 |
Jahr: | 15 September 2017 |
Umfang: | 19 S. |
Fussnoten: | Gesehen am 21.04.2020 |
Titel Quelle: | Enthalten in: Molecular systems biology |
Ort Quelle: | [London] : Nature Publishing Group UK, 2005 |
Jahr Quelle: | 2017 |
Band/Heft Quelle: | 13(2017,9) Artikel-Nummer 939, 19 Seiten |
ISSN Quelle: | 1744-4292 |
Abstract: | Abstract Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long-lived IIS mutants has been extensively documented, the causal mechanisms contributing to extended lifespan, particularly in specific tissues, remain unclear. We have characterized the proteomes of four key insulin-sensitive tissues in a long-lived Drosophila IIS mutant and control, and detected 44% of the predicted proteome (6,085 proteins). Expression of ribosome-associated proteins in the fat body was reduced in the mutant, with a corresponding, tissue-specific reduction in translation. Expression of mitochondrial electron transport chain proteins in fat body was increased, leading to increased respiration, which was necessary for IIS-mediated lifespan extension, and alone sufficient to mediate it. Proteasomal subunits showed altered expression in IIS mutant gut, and gut-specific over-expression of the RPN6 proteasomal subunit, was sufficient to increase proteasomal activity and extend lifespan, whilst inhibition of proteasome activity abolished IIS-mediated longevity. Our study thus uncovered strikingly tissue-specific responses of cellular processes to lowered IIS acting in concert to ameliorate ageing. |
DOI: | doi:10.15252/msb.20177663 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.15252/msb.20177663 |
| Volltext: https://www.embopress.org/doi/full/10.15252/msb.20177663 |
| DOI: https://doi.org/10.15252/msb.20177663 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | ageing |
| insulin/IGF |
| mitochondria |
| proteasome |
| proteome |
K10plus-PPN: | 1695282310 |
Verknüpfungen: | → Zeitschrift |
¬A¬ proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance / Tain, Luke S. [VerfasserIn]; 15 September 2017 (Online-Ressource)