Pharmacological decrease of liver stiffness is pressure-related and predicts long-term clinical outcome

• Verfasst von: Piecha, Felix Benedikt [VerfasserIn]
• Verfasst von: Poth, Tanja [VerfasserIn]
• Verfasst von: Seitz, Helmut K. [VerfasserIn]
• Verfasst von: Mueller, Sebastian [VerfasserIn]
• Titel: Pharmacological decrease of liver stiffness is pressure-related and predicts long-term clinical outcome
• Verf.angabe: Felix Piecha, Mattias Mandorfer, Teresa Peccerella, Ann-Kathrin Ozga, Tanja Poth, Anna Vonbank, Helmut Karl Seitz, Vanessa Rausch, Thomas Reiberger, and Sebastian Mueller
• E-Jahr: 2018
• Jahr: 18 September 2018
• Umfang: 11 S.
• Fussnoten: Gesehen am 21.04.2020
• Titel Quelle: Enthalten in: American journal of physiology / Gastrointestinal and liver physiology
• Ort Quelle: Bethesda, Md. : American Physiological Society, 1980
• Jahr Quelle: 2018
• Band/Heft Quelle: 315(2018), 4, Seite G484-G494
• ISSN Quelle: 1522-1547
• DOI: doi:10.1152/ajpgi.00392.2017
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1695562895

Abstract

Liver stiffness (LS) as measured by transient elastography is increasingly used to noninvasively assess liver fibrosis. However, LS is efficiently modulated by confounders like arterial and portal pressure (PP). We here study the effect of acute hemodynamic changes on LS (measured by µFibroscan) in a rodent model of cirrhosis in response to pharmacological modulation of PP by losartan, nitric oxide donors, and propranolol.