Butyrylcholinesterase levels on admission predict severity and 12-month mortality in hospitalized AIDS patients

• Verfasst von: Xu, Lijun [VerfasserIn]
• Verfasst von: Weng, Honglei [VerfasserIn]
• Titel: Butyrylcholinesterase levels on admission predict severity and 12-month mortality in hospitalized AIDS patients
• Verf.angabe: Lijun Xu, Biao Zhu, Ying Huang, Zongxing Yang, Jia Sun, Yan Xu, Jinlei Zheng, Sabine Kinloch, Michael T. Yin, Honglei Weng, and Nanping Wu
• E-Jahr: 2018
• Jahr: 15 March 2018
• Umfang: 10 S.
• Fussnoten: Gesehen am 21.04.2020
• Titel Quelle: Enthalten in: Mediators of inflammation
• Ort Quelle: Sylvania, Ohio : Hindawi Publishing Corp., 1992
• Jahr Quelle: 2018
• Band/Heft Quelle: 2018(2018) Artikel-Nummer 5201652, 10 Seiten
• ISSN Quelle: 1466-1861
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1695565509

Abstract

Background. Butyrylcholinesterase (BChE) is synthesized mainly in the liver and an important marker in many infectious/inflammatory diseases, but its role in acquired immunodeficiency syndrome (AIDS) patients is not clear. We wished to ascertain if BChE level is associated with the progression/prognosis of AIDS patients. Methods. BChE levels (in U/L) were measured in 505 patients; <4500 was defined as “low” and ≥4500 as “normal.” Associations between BChE level and CD4 count, WHO stage, body mass index (BMI), C-reactive protein (CRP) level, and duration of hospitalization were assessed. Kaplan-Meier curves and Cox proportional hazards model were used to assess associations between low BChE levels and mortality, after adjustment for age, CD4 count, WHO stage, and laboratory parameters. Results. A total of 129 patients (25.5%) had a lower BChE level. BChE was closely associated with CD4 count, WHO stage, CRP level, and BMI (all ). Eighty-four patients (16.6%) died in the first year of follow-up. One-year survival was 64.5 ± 4.5% for patients with low BChE and 87.6 ± 1.8% for those with normal BChE (log-rank, ). After adjustment for sex, age, BMI, WHO stage, and CD4 count, as well as serum levels of hemoglobin, sodium, and albumin, the hazard ratio was 1.8 (95% confidence interval, 1.0-3.2) for patients with a low BChE compared with those with a normal BChE (). Conclusion. BChE level is associated with HIV/AIDS severity and is an independent risk factor for increased mortality in AIDS patients.