| |  Online-Ressource |
|---|
| Verfasst von: | Luck, Robert [VerfasserIn]  |
|---|
| | Urban, Severino [VerfasserIn] |
|---|
| | Karakatsani, Andromachi [VerfasserIn] |
|---|
| | Harde, Eva [VerfasserIn] |
|---|
| | Sambandan, Sivakumar [VerfasserIn] |
|---|
| | Nicholson, LaShae [VerfasserIn] |
|---|
| | Haverkamp, Silke [VerfasserIn] |
|---|
| | Mann, Rebecca [VerfasserIn] |
|---|
| | Martín-Villalba, Ana [VerfasserIn] |
|---|
| | Schuman, Erin [VerfasserIn] |
|---|
| | Acker-Palmer, Amparo [VerfasserIn] |
|---|
| | Ruiz de Almodóvar, Carmen [VerfasserIn] |
|---|
| Titel: | VEGF/VEGFR2 signaling regulates hippocampal axon branching during development |
|---|
| Verf.angabe: | Robert Luck, Severino Urban, Andromachi Karakatsani, Eva Harde, Sivakumar Sambandan, LaShae Nicholson, Silke Haverkamp, Rebecca Mann, Ana Martin-Villalba, Erin Margaret Schuman, Amparo Acker-Palmer, Carmen Ruiz de Almodóvar |
|---|
| E-Jahr: | 2019 |
|---|
| Jahr: | Dec 23, 2019 |
|---|
| Umfang: | 24 S. |
|---|
| Fussnoten: | Gesehen am 21.04.2020 |
|---|
| Titel Quelle: | Enthalten in: eLife |
|---|
| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
|---|
| Jahr Quelle: | 2019 |
|---|
| Band/Heft Quelle: | 8(2019) Artikel-Nummer e49818, 24 Seiten |
|---|
| ISSN Quelle: | 2050-084X |
|---|
| Abstract: | Axon branching is crucial for proper formation of neuronal networks. Although originally identified as an angiogenic factor, VEGF also signals directly to neurons to regulate their development and function. Here we show that VEGF and its receptor VEGFR2 (also known as KDR or FLK1) are expressed in mouse hippocampal neurons during development, with VEGFR2 locally expressed in the CA3 region. Activation of VEGF/VEGFR2 signaling in isolated hippocampal neurons results in increased axon branching. Remarkably, inactivation of VEGFR2 also results in increased axon branching in vitro and in vivo. The increased CA3 axon branching is not productive as these axons are less mature and form less functional synapses with CA1 neurons. Mechanistically, while VEGF promotes the growth of formed branches without affecting filopodia formation, loss of VEGFR2 increases the number of filopodia and enhances the growth rate of new branches. Thus, a controlled VEGF/VEGFR2 signaling is required for proper CA3 hippocampal axon branching during mouse hippocampus development. |
|---|
| DOI: | doi:10.7554/eLife.49818 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.49818 |
|---|
| | Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927742 |
|---|
| | DOI: https://doi.org/10.7554/eLife.49818 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | axon branching |
|---|
| | develomental neuroscience |
|---|
| | hippocampus |
|---|
| | neuro-vascular link |
|---|
| | VEGF |
|---|
| | VEGFR2 |
|---|
| K10plus-PPN: | 1695565800 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
VEGF/VEGFR2 signaling regulates hippocampal axon branching during development / Luck, Robert [VerfasserIn]; Dec 23, 2019 (Online-Ressource)
