| |  Online-Ressource |
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| Verfasst von: | Yin, Yefeng [VerfasserIn]  |
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| | Liu, Li [VerfasserIn] |
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| | Zhao, Zhefu [VerfasserIn] |
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| | Yin, Libo [VerfasserIn] |
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| | Bauer, Nathalie [VerfasserIn] |
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| | Nwaeburu, Clifford C. [VerfasserIn] |
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| | Gladkich, Jury [VerfasserIn] |
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| | Gross, Wolfgang [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Sticht, Carsten [VerfasserIn] |
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| | Gretz, Norbert [VerfasserIn] |
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| | Strobel, Oliver [VerfasserIn] |
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| | Herr, Ingrid [VerfasserIn] |
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| Titel: | Simvastatin inhibits Sonic Hedgehog signaling and stemness features of pancreatic cancer |
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| Verf.angabe: | Yefeng Yin, Li Liu, Zhefu Zhao, Libo Yin, Nathalie Bauer, Clifford C. Nwaeburu, Jury Gladkich, Wolfgang Gross, Thilo Hackert, Carsten Sticht, Norbert Gretz, Oliver Strobel, Ingrid Herr |
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| E-Jahr: | 2018 |
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| Jahr: | 10 July 2018 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 21.04.2020 |
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| Titel Quelle: | Enthalten in: Cancer letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 426(2018), Seite 14-24 |
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| ISSN Quelle: | 1872-7980 |
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| Abstract: | Pancreatic ductal adenocarcinoma (PDA) has poor therapeutic options. Recent patient studies indicate that cholesterol-lowering statins have anti-tumor capacities. We examined several established and primary PDA and normal cell lines as well as PDA patient tissues (n=68). We found that simvastatin inhibited viability, stemness, tumor growth and metastasis and that it enhanced the efficacy of gemcitabine. These changes were associated with modulation of Shh-related gene expression. Overexpression of Shh prevented the anti-cancer effect of simvastatin, and inhibition of Shh mimicked the simvastatin effect. In PDA tissues, expression levels of Shh, downstream mediators of Shh and progression markers, namely, cMet, CxCR4 and Vimentin, were lower when patients were prescribed statin medication prior to surgery. These results suggested that statins are cost effective and well-tolerated drugs for prevention and co-treatment of PDA. |
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| DOI: | doi:10.1016/j.canlet.2018.04.001 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.canlet.2018.04.001 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0304383518302520 |
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| | DOI: https://doi.org/10.1016/j.canlet.2018.04.001 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer stem cells |
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| | Pancreatic cancer |
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| | Simvastatin |
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| | Sonic Hedgehog |
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| K10plus-PPN: | 1695565843 |
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| Verknüpfungen: | → Zeitschrift |
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Simvastatin inhibits Sonic Hedgehog signaling and stemness features of pancreatic cancer / Yin, Yefeng [VerfasserIn]; 10 July 2018 (Online-Ressource)
