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| Verfasst von: | Follain, Gautier [VerfasserIn]  |
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| | Osmani, Naël [VerfasserIn] |
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| | Azevedo, Ana Sofia [VerfasserIn] |
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| | Allio, Guillaume [VerfasserIn] |
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| | Mercier, Luc [VerfasserIn] |
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| | Karreman, Matthia A. [VerfasserIn] |
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| | Solecki, Gergely [VerfasserIn] |
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| | Garcia Leòn, Marìa Jesùs [VerfasserIn] |
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| | Lefebvre, Olivier [VerfasserIn] |
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| | Fekonja, Nina [VerfasserIn] |
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| | Hille, Claudia [VerfasserIn] |
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| | Chabannes, Vincent [VerfasserIn] |
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| | Dollé, Guillaume [VerfasserIn] |
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| | Metivet, Thibaut [VerfasserIn] |
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| | Hovsepian, François Der [VerfasserIn] |
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| | Prudhomme, Christophe [VerfasserIn] |
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| | Pichot, Angélique [VerfasserIn] |
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| | Paul, Nicodème [VerfasserIn] |
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| | Carapito, Raphaël [VerfasserIn] |
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| | Bahram, Siamak [VerfasserIn] |
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| | Ruthensteiner, Bernhard [VerfasserIn] |
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| | Kemmling, André [VerfasserIn] |
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| | Siemonsen, Susanne [VerfasserIn] |
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| | Schneider, Tanja [VerfasserIn] |
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| | Fiehler, Jens [VerfasserIn] |
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| | Glatzel, Markus [VerfasserIn] |
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| | Winkler, Frank [VerfasserIn] |
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| | Schwab, Yannick [VerfasserIn] |
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| | Pantel, Klaus [VerfasserIn] |
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| | Harlepp, Sébastien [VerfasserIn] |
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| | Goetz, Jacky G. [VerfasserIn] |
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| Titel: | Hemodynamic forces tune the arrest, adhesion, and extravasation of circulating tumor cells |
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| Verf.angabe: | Gautier Follain, Naël Osmani, Ana Sofia Azevedo, Guillaume Allio, Luc Mercier, Matthia A. Karreman, Gergely Solecki, Marìa Jesùs Garcia Leòn, Olivier Lefebvre, Nina Fekonja, Claudia Hille, Vincent Chabannes, Guillaume Dollé, Thibaut Metivet, François Der Hovsepian, Christophe Prudhomme, Angélique Pichot, Nicodème Paul, Raphaël Carapito, Siamak Bahram, Bernhard Ruthensteiner, André Kemmling, Susanne Siemonsen, Tanja Schneider, Jens Fiehler, Markus Glatzel, Frank Winkler, Yannick Schwab, Klaus Pantel, Sébastien Harlepp, and Jacky G. Goetz |
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| E-Jahr: | 2018 |
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| Jahr: | April 9, 2018 |
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| Umfang: | 20 S. |
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| Fussnoten: | Gesehen am 22.04.2020 |
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| Titel Quelle: | Enthalten in: Developmental cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2001 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 45(2018), 1, Seite 33-52 |
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| ISSN Quelle: | 1878-1551 |
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| Abstract: | Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest and the extravasation of circulating tumor cells (CTCs) in vivo. Using the zebrafish embryo, we show that arrest of CTCs occurs in vessels with favorable flow profiles where flow forces control the adhesion efficacy of CTCs to the endothelium. We biophysically identified the threshold values of flow and adhesion forces allowing successful arrest of CTCs. In addition, flow forces fine-tune tumor cell extravasation by impairing the remodeling properties of the endothelium. Importantly, we also observe endothelial remodeling at arrest sites of CTCs in mouse brain capillaries. Finally, we observed that human supratentorial brain metastases preferably develop in areas with low perfusion. These results demonstrate that hemodynamic profiles at metastatic sites regulate key steps of extravasation preceding metastatic outgrowth. |
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| DOI: | doi:10.1016/j.devcel.2018.02.015 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.devcel.2018.02.015 |
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| | DOI: https://doi.org/10.1016/j.devcel.2018.02.015 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | biomechanics |
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| | blood flow |
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| | Brain Neoplasms |
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| | Breast Neoplasms |
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| | cell adhesion |
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| | Cell Adhesion |
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| | Cell Cycle |
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| | Cerebrovascular Circulation |
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| | circulating tumor cells |
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| | Embryo, Nonmammalian |
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| | endothelial remodeling |
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| | Endothelium, Vascular |
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| | extravasation |
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| | Female |
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| | Hemodynamics |
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| | Humans |
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| | Lung Neoplasms |
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| | Male |
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| | Melanoma |
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| | metastasis |
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| | Mice |
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| | Mice, Inbred BALB C |
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| | Mice, Nude |
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| | Neoplastic Cells, Circulating |
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| | Retrospective Studies |
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| | Tumor Cells, Cultured |
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| | zebrafish |
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| | Zebrafish |
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| K10plus-PPN: | 1695622391 |
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| Verknüpfungen: | → Zeitschrift |
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Hemodynamic forces tune the arrest, adhesion, and extravasation of circulating tumor cells / Follain, Gautier [VerfasserIn]; April 9, 2018 (Online-Ressource)
