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Verfasst von:Schoeps, Anja [VerfasserIn]   i
 Nebié, Eric [VerfasserIn]   i
 Fisker, Ane B. [VerfasserIn]   i
 Sié, Ali [VerfasserIn]   i
 Zakane, Alphonse [VerfasserIn]   i
 Müller, Olaf [VerfasserIn]   i
 Aaby, Peter [VerfasserIn]   i
 Becher, Heiko [VerfasserIn]   i
Titel:No effect of an additional early dose of measles vaccine on hospitalization or mortality in children
Titelzusatz:a randomized controlled trial
Verf.angabe:Anja Schoeps, Eric Nebié, Ane Baerent Fisker, Ali Sié, Alphonse Zakane, Olaf Müller, Peter Aaby, Heiko Becher
E-Jahr:2018
Jahr:6 March 2018
Umfang:7 S.
Fussnoten:Gesehen am 22.04.2020
Titel Quelle:Enthalten in: Vaccine
Ort Quelle:Amsterdam : Elsevier, 1983
Jahr Quelle:2018
Band/Heft Quelle:36(2018), 15, Seite 1965-1971
ISSN Quelle:1873-2518
Abstract:Background - Non-specific effects (NSEs) of vaccines have increasingly gained attention in recent years. Recent studies suggest that live vaccines, such as measles vaccine (MV), have beneficial effects on health, while inactivated vaccines, such as the diphtheria-tetanus-pertussis (DTP) vaccine, may have harmful effects. If this is the case, it should improve child health to move MV closer to the last vaccination with DTP. The objective of this study was to investigate the NSEs of an additional early dose of MV on hospitalization or mortality. - Methods - Children were randomized to receive either the standard MV at 9months (control) or an additional early dose of MV 4weeks after the third dose of DTP-containing Pentavalent vaccine and the standard MV at 9months (intervention). In this analysis of a secondary outcome in the trial, we investigated the effect of the intervention on a composite endpoint of over-night hospitalization with or without recovery, or death without previous hospitalization, in children between 4.5 and 36months of age in the Nouna HDSS in Burkina Faso. We used Cox proportional hazards regression with repeated events and time since study enrolment as underlying time-scale. - Results - Among 2258 children in the intervention and 2238 children in the control group we observed a total of 464 episodes of hospitalization or mortality. There was no difference between intervention and control group (HR=1.00, 95% Confidence Interval (CI) 0.83-1.20). Results from the per-protocol and intention-to-treat analysis were similar. Although no significant, results suggest a possible beneficial effect of early MV in children that had not been exposed to an OPV campaign after enrolment (HR=0.83, 95% CI 0.55-1.29). - Conclusions - We did not detect any effect of early MV on subsequent hospitalization or mortality. However, possible effects of early MV could have been obscured by NSEs of the frequent OPV campaigns. Registration: The trial was registered at ClinicalTrials.gov, NCT01644721
DOI:doi:10.1016/j.vaccine.2018.02.104
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.vaccine.2018.02.104
 Volltext: http://www.sciencedirect.com/science/article/pii/S0264410X18303141
 DOI: https://doi.org/10.1016/j.vaccine.2018.02.104
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Africa
 Childhood vaccination
 Hospitalization
 Measles vaccine
 Mortality
 Non-specific effect
K10plus-PPN:1695635752
Verknüpfungen:→ Zeitschrift

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