Emerging RNA-binding roles in the TRIM family of ubiquitin ligases

• Verfasst von: Williams, Felix Preston [VerfasserIn]
• Verfasst von: Haubrich, Kevin [VerfasserIn]
• Verfasst von: Hennig, Janosch [VerfasserIn]
• Titel: Emerging RNA-binding roles in the TRIM family of ubiquitin ligases
• Verf.angabe: Felix Preston Williams, Kevin Haubrich, Cecilia Perez-Borrajero and Janosch Hennig
• E-Jahr: 2019
• Jahr: May 23, 2019
• Umfang: 22 S.
• Fussnoten: Gesehen am 22.04.2020
• Titel Quelle: Enthalten in: Biological chemistry
• Ort Quelle: Berlin [u.a.] : de Gruyter, 1996
• Jahr Quelle: 2019
• Band/Heft Quelle: 400(2019), 11, Seite 1443-1464
• ISSN Quelle: 1437-4315
• DOI: doi:10.1515/hsz-2019-0158
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1695637801

Abstract

TRIM proteins constitute a large, diverse and ancient protein family which play a key role in processes including cellular differentiation, autophagy, apoptosis, DNA repair, and tumour suppression. Mostly known and studied through the lens of their ubiquitination activity as E3 ligases, it has recently emerged that many of these proteins are involved in direct RNA binding through their NHL or PRY/SPRY domains. We summarise the current knowledge concerning the mechanism of RNA binding by TRIM proteins and its biological role. We discuss how RNA-binding relates to their previously described functions such as E3 ubiquitin ligase activity, and we will consider the potential role of enrichment in membrane-less organelles.</p></section>