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Status: Bibliographieeintrag

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Verfasst von:Willis, Franziska [VerfasserIn]   i
 Schimmack, Simon [VerfasserIn]   i
 Uhl, Matthias [VerfasserIn]   i
 Häfner, Matthias [VerfasserIn]   i
 Mechtersheimer, Gunhild [VerfasserIn]   i
 Hinz, Ulf [VerfasserIn]   i
 Schmidt, Thomas [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Fröhling, Stefan [VerfasserIn]   i
 Schneider, Martin [VerfasserIn]   i
Titel:Significance of intraoperative radiation therapy and high cumulative radiation doses in retroperitoneal soft tissue sarcoma
Verf.angabe:Franziska Willis, Simon Schimmack, Matthias Uhl, Matthias F. Haefner, Gunhild Mechtersheimer, Ulf Hinz, Thomas Schmidt, Jürgen Debus, Stefan Fröhling, Martin Schneider
Jahr:2020
Jahr des Originals:2019
Umfang:9 S.
Fussnoten:Available online 17 December 2019 ; Gesehen am 22.04.2020
Titel Quelle:Enthalten in: European journal of surgical oncology
Ort Quelle:Burlington, Mass. : Harcourt, 1995
Jahr Quelle:2020
Band/Heft Quelle:46(2020), 5, Seite 905-913
ISSN Quelle:1532-2157
Abstract:Introduction - In retroperitoneal soft tissue sarcoma (STS) local recurrence (LR) rates remain high despite more aggressive surgical approaches. Since wide resection margins cannot be achieved in all patients, application of intraoperative radiation therapy (IORT) has been frequently discussed. Still, the significance of IORT in multimodal treatment of retroperitoneal STS remains unclear. - Material and methods - Patients undergoing resection of primary or recurrent retroperitoneal STS at the University of Heidelberg Department of General, Visceral and Transplantation Surgery were retrospectively analyzed. Univariate Kaplan-Meyer and multivariate Cox regression analyses were performed to identify predictors of LR-free survival and to investigate the impact of IORT and high cumulative radiation doses. Analyses with propensity-score matched subgroups for IORT and cumulative radiation dose were performed to control for selection bias. Subgroup analyses for patients with retroperitoneal liposarcoma were likewise performed. - Results - 272 patients were identified. Recurrent tumors, histology of dedifferentiated liposarcoma or unclassified sarcoma and microscopically incomplete resection were associated with decreased LR-free survival. In liposarcoma, only recurrent and dedifferentiated tumors were confirmed as poor prognostic factors concerning LR. IORT and cumulative radiation doses exceeding 60 Gy did not influence LR rates (estimated 5-year LR-free survival: IORT: 39%, non-IORT: 46%; p = 0.79). - Conclusion - In this retrospective evaluation, additional application of IORT does not significantly influence oncological outcome in retroperitoneal soft tissue sarcoma. Randomized trials are needed to clarify the benefit of IORT.
DOI:doi:10.1016/j.ejso.2019.12.014
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.ejso.2019.12.014
 Volltext: http://www.sciencedirect.com/science/article/pii/S0748798319315070
 DOI: https://doi.org/10.1016/j.ejso.2019.12.014
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:IORT
 Radiation therapy
 Recurrence analysis
 Retroperitoneal soft tissue sarcoma
 Surgery
 Survival analysis
K10plus-PPN:1695640292
Verknüpfungen:→ Zeitschrift

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