| |  Online-Ressource |
|---|
| Verfasst von: | Willis, Franziska [VerfasserIn]  |
|---|
| | Schimmack, Simon [VerfasserIn] |
|---|
| | Uhl, Matthias [VerfasserIn] |
|---|
| | Häfner, Matthias [VerfasserIn] |
|---|
| | Mechtersheimer, Gunhild [VerfasserIn] |
|---|
| | Hinz, Ulf [VerfasserIn] |
|---|
| | Schmidt, Thomas [VerfasserIn] |
|---|
| | Debus, Jürgen [VerfasserIn] |
|---|
| | Fröhling, Stefan [VerfasserIn] |
|---|
| | Schneider, Martin [VerfasserIn] |
|---|
| Titel: | Significance of intraoperative radiation therapy and high cumulative radiation doses in retroperitoneal soft tissue sarcoma |
|---|
| Verf.angabe: | Franziska Willis, Simon Schimmack, Matthias Uhl, Matthias F. Haefner, Gunhild Mechtersheimer, Ulf Hinz, Thomas Schmidt, Jürgen Debus, Stefan Fröhling, Martin Schneider |
|---|
| Jahr: | 2020 |
|---|
| Jahr des Originals: | 2019 |
|---|
| Umfang: | 9 S. |
|---|
| Fussnoten: | Available online 17 December 2019 ; Gesehen am 22.04.2020 |
|---|
| Titel Quelle: | Enthalten in: European journal of surgical oncology |
|---|
| Ort Quelle: | Burlington, Mass. : Harcourt, 1995 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 46(2020), 5, Seite 905-913 |
|---|
| ISSN Quelle: | 1532-2157 |
|---|
| Abstract: | Introduction - In retroperitoneal soft tissue sarcoma (STS) local recurrence (LR) rates remain high despite more aggressive surgical approaches. Since wide resection margins cannot be achieved in all patients, application of intraoperative radiation therapy (IORT) has been frequently discussed. Still, the significance of IORT in multimodal treatment of retroperitoneal STS remains unclear. - Material and methods - Patients undergoing resection of primary or recurrent retroperitoneal STS at the University of Heidelberg Department of General, Visceral and Transplantation Surgery were retrospectively analyzed. Univariate Kaplan-Meyer and multivariate Cox regression analyses were performed to identify predictors of LR-free survival and to investigate the impact of IORT and high cumulative radiation doses. Analyses with propensity-score matched subgroups for IORT and cumulative radiation dose were performed to control for selection bias. Subgroup analyses for patients with retroperitoneal liposarcoma were likewise performed. - Results - 272 patients were identified. Recurrent tumors, histology of dedifferentiated liposarcoma or unclassified sarcoma and microscopically incomplete resection were associated with decreased LR-free survival. In liposarcoma, only recurrent and dedifferentiated tumors were confirmed as poor prognostic factors concerning LR. IORT and cumulative radiation doses exceeding 60 Gy did not influence LR rates (estimated 5-year LR-free survival: IORT: 39%, non-IORT: 46%; p = 0.79). - Conclusion - In this retrospective evaluation, additional application of IORT does not significantly influence oncological outcome in retroperitoneal soft tissue sarcoma. Randomized trials are needed to clarify the benefit of IORT. |
|---|
| DOI: | doi:10.1016/j.ejso.2019.12.014 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ejso.2019.12.014 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0748798319315070 |
|---|
| | DOI: https://doi.org/10.1016/j.ejso.2019.12.014 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | IORT |
|---|
| | Radiation therapy |
|---|
| | Recurrence analysis |
|---|
| | Retroperitoneal soft tissue sarcoma |
|---|
| | Surgery |
|---|
| | Survival analysis |
|---|
| K10plus-PPN: | 1695640292 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Significance of intraoperative radiation therapy and high cumulative radiation doses in retroperitoneal soft tissue sarcoma / Willis, Franziska [VerfasserIn]; 2020 (Online-Ressource)
