| |  Online-Ressource |
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| Verfasst von: | Gröner, Jan [VerfasserIn]  |
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| | Valkanou, Aikaterini [VerfasserIn] |
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| | Kender, Zoltán [VerfasserIn] |
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| | Pfeiffenberger, Jan [VerfasserIn] |
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| | Kihm, Lars Philipp [VerfasserIn] |
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| | Fleming, Thomas [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| | Kopf, Stefan [VerfasserIn] |
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| Titel: | Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes |
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| Verf.angabe: | Jan Benedikt Groener, Aikaterini Valkanou, Zoltan Kender, Jan Pfeiffenberger, Lars Kihm, Thomas Fleming, Peter Paul Nawroth, Stefan Kopf |
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| E-Jahr: | 2019 |
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| Jahr: | September 19, 2019 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 23.04.2020 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 14(2019,9) Artikel-Nummer e0222771, 11 Seiten |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | Asprosin is a counter-regulatory hormone to insulin which plays a role in fasting. It may therefore also play a role in hypoglycaemia unawareness, which has been subsequently examined in this pilot study. Intravenous glucose tolerance test was used to induce controlled hyperglycemia whereas a hyperinsulinemic clamp test was used to induce a controlled hypoglycaemia in 15 patients with diabetes type 1, with and without hypoglycaemia unawareness. Changes in asprosin plasma levels did not differ between patients with and without hypoglycaemia unawareness. However, nine patients with insulin resistance as well as higher liver stiffness values and low-density lipoprotein but lower high-density lipoprotein levels did not show the expected increase in asprosin plasma levels during hypoglycemia. Therefore, insulin resistance and alterations in liver structure, most likely early stages of non-alcoholic fatty liver disease, seem to be relevant in type 1 diabetes and do not only lead to elevated plasma levels of asprosin, but also to a blunted asprosin response in hypoglycemia. |
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| DOI: | doi:10.1371/journal.pone.0222771 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1371/journal.pone.0222771 |
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| | Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222771 |
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| | DOI: https://doi.org/10.1371/journal.pone.0222771 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Blood plasma |
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| | Blood sugar |
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| | Diabetes mellitus |
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| | Glucose |
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| | Hypoglycemia |
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| | Hypoglycemics |
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| | Insulin |
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| | Insulin resistance |
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| K10plus-PPN: | 169577843X |
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| Verknüpfungen: | → Zeitschrift |
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Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes / Gröner, Jan [VerfasserIn]; September 19, 2019 (Online-Ressource)
