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Status: Bibliographieeintrag

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Verfasst von:Hirjak, Dusan [VerfasserIn]   i
 Rashidi, Mahmoud [VerfasserIn]   i
 Kubera, Katharina Maria [VerfasserIn]   i
 Schmitgen, Mike [VerfasserIn]   i
 Weisbrod, Matthias [VerfasserIn]   i
 Tost, Heike [VerfasserIn]   i
 Wolf, Robert Christian [VerfasserIn]   i
Titel:Patterns of co-altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders
Verf.angabe:Dusan Hirjak, Mahmoud Rashidi, Stefan Fritze, Alina L. Bertolino, Lena S. Geiger, Zhenxiang Zang, Katharina M. Kubera, Mike M. Schmitgen, Fabio Sambataro, Vince D. Calhoun, Matthias Weisbrod, Heike Tost, Robert C. Wolf
E-Jahr:2019
Jahr:12 August 2019
Umfang:13 S.
Fussnoten:Gesehen am 27.04.2020
Titel Quelle:Enthalten in: Journal of time series analysis
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1980
Jahr Quelle:2019
Band/Heft Quelle:40(2019), 17, Seite 5029-5041
ISSN Quelle:1467-9892
Abstract:Neurological soft signs (NSS) comprise a broad range of subtle neurological deficits and are considered to represent external markers of sensorimotor dysfunction frequently found in mental disorders of presumed neurodevelopmental origin. Although NSS frequently occur in schizophrenia spectrum disorders (SSD), specific patterns of co-altered brain structure and function underlying NSS in SSD have not been investigated so far. It is unclear whether gray matter volume (GMV) alterations or aberrant brain activity or a combination of both, are associated with NSS in SSD. Here, 37 right-handed SSD patients and 37 matched healthy controls underwent motor assessment and magnetic resonance imaging (MRI) at 3 T. NSS were examined on the Heidelberg NSS scale. We used a multivariate data fusion technique for multimodal MRI data—multiset canonical correlation and joint independent component analysis (mCCA + jICA)—to investigate co-altered patterns of GMV and intrinsic neural fluctuations (INF) in SSD patients exhibiting NSS. The mCCA + jICA model indicated two joint group-discriminating components (temporoparietal/cortical sensorimotor and frontocerebellar/frontoparietal networks) and one modality-specific group-discriminating component (p < .05, FDR corrected). NSS motor score was associated with joint frontocerebellar/frontoparietal networks in SSD patients. This study highlights complex neural pathomechanisms underlying NSS in SSD suggesting aberrant structure and function, predominantly in cortical and cerebellar systems that critically subserve sensorimotor dynamics and psychomotor organization.
DOI:doi:10.1002/hbm.24755
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/hbm.24755
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24755
 DOI: https://doi.org/10.1002/hbm.24755
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:gray matter volume
 mCCA + jICA
 motor abnormalities
 neurological soft signs
 resting-state functional MRI
 schizophrenia spectrum disorders
K10plus-PPN:1696263689
Verknüpfungen:→ Zeitschrift

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