| |  Online-Ressource |
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| Verfasst von: | Fröse, Julia [VerfasserIn]  |
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| | Chen, Michelle B. [VerfasserIn] |
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| | Hebron, Katie E. [VerfasserIn] |
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| | Reinhardt, Ferenc [VerfasserIn] |
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| | Hajal, Cynthia [VerfasserIn] |
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| | Zijlstra, Andries [VerfasserIn] |
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| | Kamm, Roger D. [VerfasserIn] |
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| | Weinberg, Robert A. [VerfasserIn] |
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| Titel: | Epithelial-Mesenchymal transition induces podocalyxin to promote extravasation via ezrin signaling |
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| Verf.angabe: | Julia Fröse, Michelle B. Chen, Katie E. Hebron, Ferenc Reinhardt, Cynthia Hajal, Andries Zijlstra, Roger D. Kamm, and Robert A. Weinberg |
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| E-Jahr: | 2018 |
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| Jahr: | 24 July 2018 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 28.04.2020 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 24(2018), 4, Seite 962-972 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | The epithelial-mesenchymal transition (EMT) endows carcinoma cells with traits needed to complete many of the steps leading to metastasis formation, but its contributions specifically to the late step of extravasation remain understudied. We find that breast cancer cells that have undergone an EMT extravasate more efficiently from blood vessels both in vitro and in vivo. Analysis of gene expression changes associated with the EMT program led to the identification of an EMT-induced cell-surface protein, podocalyxin (PODXL), as a key mediator of extravasation in mesenchymal breast and pancreatic carcinoma cells. PODXL promotes extravasation through direct interaction of its intracellular domain with the cytoskeletal linker protein ezrin. Ezrin proceeds to establish dorsal cortical polarity, enabling the transition of cancer cells from a non-polarized, rounded cell morphology to an invasive extravasation-competent shape. Hence, the EMT program can directly enhance the efficiency of extravasation and subsequent metastasis formation through a PODXL-ezrin signaling axis. |
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| DOI: | doi:10.1016/j.celrep.2018.06.092 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2018.06.092 |
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| | DOI: https://doi.org/10.1016/j.celrep.2018.06.092 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Breast Neoplasms |
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| | Cell Line, Tumor |
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| | Cytoskeletal Proteins |
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| | EMT |
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| | Epithelial-Mesenchymal Transition |
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| | extravasation |
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| | ezrin |
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| | Female |
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| | Heterografts |
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| | Humans |
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| | Lung Neoplasms |
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| | Male |
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| | metastasis |
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| | Mice |
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| | Mice, Inbred NOD |
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| | Mice, SCID |
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| | Pancreatic Neoplasms |
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| | PODXL |
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| | Sialoglycoproteins |
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| | Signal Transduction |
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| K10plus-PPN: | 1696460077 |
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| Verknüpfungen: | → Zeitschrift |
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Epithelial-Mesenchymal transition induces podocalyxin to promote extravasation via ezrin signaling / Fröse, Julia [VerfasserIn]; 24 July 2018 (Online-Ressource)
