Effect of the number of pregnancies on mortality risk in HIV-infected women

• Verfasst von: Yoo, Hyunsuk [VerfasserIn]
• Verfasst von: Bärnighausen, Till [VerfasserIn]
• Titel: Effect of the number of pregnancies on mortality risk in HIV-infected women
• Titelzusatz: a prospective cohort study in rural KwaZulu-Natal, South Africa
• Verf.angabe: Hyunsuk Yoo, Juyeon Lee, Jae-Joon Yim, Till Bärnighausen, Frank Tanser, Sue K. Park
• E-Jahr: 2018
• Jahr: 02 August 2018
• Umfang: 10 S.
• Fussnoten: Gesehen am 29.04.2020
• Titel Quelle: Enthalten in: Aids and behavior
• Ort Quelle: Dordrecht [u.a.] : Springer Science + Business Media B.V, 1997
• Jahr Quelle: 2018
• Band/Heft Quelle: 22(2018), 12, Seite 3971-3980
• ISSN Quelle: 1573-3254
• DOI: doi:10.1007/s10461-018-2232-0
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1696838975

Abstract

We investigated whether mortality risk increases with the number of full-term pregnancies in HIV-infected women. Our study is based on data from the ACDIS cohort, collected in rural KwaZulu-Natal, South Africa. Mortality risk for different number of pregnancies in HIV-infected women was analyzed using Cox proportional hazards model. The risk of TB or AIDS mortality in HIV-uninfected women did not change with the number of full-term pregnancies, while the corresponding risk increased markedly in HIV-infected women. The risk of TB or AIDS mortality increased 1.48-fold (95% CI 1.25-1.75), 1.76-fold (95% CI 1.45-2.13), and 1.59-fold (95% CI 1.31-1.94) for one, two, and three or more full-term pregnancies compared to none, respectively. Finally, women who are young (age < 26) have greater risk of TB or AIDS mortality compared to women who are old (age ≥ 26), and women residing in rural areas have greater risk compared to women who reside in non-rural areas.