The increase in hemoglobin concentration with altitude varies among human populations

• Verfasst von: Gassmann, Max [VerfasserIn]
• Verfasst von: Mairbäurl, Heimo [VerfasserIn]
• Verfasst von: Livshits, Leonid [VerfasserIn]
• Verfasst von: Seide, Svenja [VerfasserIn]
• Verfasst von: Hackbusch, Matthes [VerfasserIn]
• Verfasst von: Malczyk, Monika [VerfasserIn]
• Verfasst von: Kraut, Simone [VerfasserIn]
• Verfasst von: Gassmann, Norina N. [VerfasserIn]
• Verfasst von: Weißmann, Norbert [VerfasserIn]
• Verfasst von: Muckenthaler, Martina [VerfasserIn]
• Titel: The increase in hemoglobin concentration with altitude varies among human populations
• Verf.angabe: Max Gassmann, Heimo Mairbäurl, Leonid Livshits, Svenja Seide, Matthes Hackbusch, Monika Malczyk, Simone Kraut, Norina N. Gassmann, Norbert Weissmann, and Martina U. Muckenthaler
• E-Jahr: 2019
• Jahr: 30 June 2019
• Umfang: 17 S.
• Fussnoten: Gesehen am 29.04.2020
• Titel Quelle: Enthalten in: New York Academy of SciencesAnnals of the New York Academy of Sciences
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1877
• Jahr Quelle: 2019
• Band/Heft Quelle: 1450(2019), Seite 204-220
• ISSN Quelle: 1749-6632
• DOI: doi:10.1111/nyas.14136
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: anemia
• Sach-SW: ethnicity
• Sach-SW: excessive erythrocytosis
• Sach-SW: infants
• Sach-SW: newborns
• Sach-SW: pregnancy
• K10plus-PPN: 1696854474

Abstract

Decreased oxygen availability at high altitude requires physiological adjustments allowing for adequate tissue oxygenation. One such mechanism is a slow increase in the hemoglobin concentration ([Hb]) resulting in elevated [Hb] in high-altitude residents. Diagnosis of anemia at different altitudes requires reference values for [Hb]. Our aim was to establish such values based on published data of residents living at different altitudes by applying meta-analysis and multiple regressions. Results show that [Hb] is increased in all high-altitude residents. However, the magnitude of increase varies among the regions analyzed and among ethnic groups within a region. The highest increase was found in residents of the Andes (1 g/dL/1000 m), but this increment was smaller in all other regions of the world (0.6 g/dL/1000 m). While sufficient data exist for adult males and females showing that sex differences in [Hb] persist with altitude, data for infants, children, and pregnant women are incomplete preventing such analyses. Because WHO reference values were originally based on [Hb] of South American people, we conclude that individual reference values have to be defined for ethnic groups to reliably diagnose anemia and erythrocytosis in high-altitude residents. Future studies need to test their applicability for children of different ages and pregnant women.