Is there a role for functional MRI for the assessment of extracapsular extension in prostate cancer?

• Verfasst von: Sertdemir, Metin [VerfasserIn]
• Verfasst von: Weidner, Anja [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Häcker, Axel [VerfasserIn]
• Verfasst von: Weiß, Christel [VerfasserIn]
• Verfasst von: Hausmann, Daniel [VerfasserIn]
• Verfasst von: Attenberger, Ulrike [VerfasserIn]
• Titel: Is there a role for functional MRI for the assessment of extracapsular extension in prostate cancer?
• Verf.angabe: Metin Sertdemir, Anja M. Weidner, Stefan O. Schoenberg, John N. Morelli, Axel Haecker, Matthias Kirchner, Christel Weiss, Daniel Hausmann, Dietmar J. Dinter and Ulrike I. Attenberger
• E-Jahr: 2018
• Jahr: January 2018
• Umfang: 6 S.
• Fussnoten: Gesehen am 29.04.2020
• Titel Quelle: Enthalten in: Anticancer research
• Ort Quelle: Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004
• Jahr Quelle: 2018
• Band/Heft Quelle: 38(2018), 1, Seite 427-432
• ISSN Quelle: 1791-7530
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: diffusion weighted MRI
• Sach-SW: dynamic contrast-enhanced MRI
• Sach-SW: extracapsular extension
• Sach-SW: Magnetic resonance imaging
• Sach-SW: prostate cancer
• K10plus-PPN: 1696855810

Abstract

Background/Aim: Exctracapsular extension (ECE) in prostate cancer has a high impact on treatment decision. MRI might predict presence of ECE non-invasively. Patients and Methods: Triplanar T2w-sequences, DWI (diffusion weighted imaging) and DCE (dynamic contrast-enhanced imaging) of 34 patients with PCa were analyzed to prior prostatectomy. Sensitivity (SS) and specificity (SP) of T2w, apparent diffusion coefficient (ADC), plasma flow (PF) and mean transit time (MTT) normalized by PCa/normal tissue ratio for prediction of CI (capsular infiltration)/ECE were determined by area-under-the-receiver-operating-characteristics analysis. Results: SS/SP for detecting ECE was 29/85. AUC (area under the curve) of ECE cases was 0.98/0.92/0.69 (cut-off-ratios 3.2/0.51/0.46), SS 93/100/86% and SP 95/80/50% for PF-/MTT-/ADC-ratios, respectively. PF- and MTT-ratios between CI and without CI/ECE differed significantly (PF, p<0.0001; MTT, p=0.0134) with SS/SP 84/89% for PF and SS/SP 52/100% for MTT-ratios. No significant differences regarding ADC-ratios were identified. Conclusion: ECE/CI can be assessed by quantitative DCE analysis with great diagnostic confidence and higher specificity than ADC.