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Verfasst von:Hancox, Jules C. [VerfasserIn]   i
 James, Andrew F. [VerfasserIn]   i
 Marrion, Neil V. [VerfasserIn]   i
 Zhang, Henggui [VerfasserIn]   i
 Thomas, Dierk [VerfasserIn]   i
Titel:Novel ion channel targets in atrial fibrillation
Verf.angabe:Jules C. Hancox, Andrew F. James, Neil V. Marrion, Henggui Zhang, Dierk Thomas
E-Jahr:2016
Jahr:17 March 2016
Umfang:12 S.
Fussnoten:Gesehen am 30.04.2020
Titel Quelle:Enthalten in: Expert opinion on therapeutic targets
Ort Quelle:Abingdon, Oxon : Routledge, Taylor & Francis, 1997
Jahr Quelle:2016
Band/Heft Quelle:20(2016), 8, Seite 947-958
ISSN Quelle:1744-7631
Abstract:Introduction: Atrial fibrillation (AF) is the most common arrhythmia in humans. It is progressive and the development of electrical and structural remodeling makes early intervention desirable. Existing antiarrhythmic pharmacological approaches are not always effective and can produce unwanted side effects. Additional atrial-selective antiarrhythmic strategies are therefore desirable.Areas covered: Evidence for three novel ion channel atrial-selective therapeutic targets is evaluated: atrial-selective fast sodium channel current (INa) inhibition; small conductance calcium-activated potassium (SK) channels; and two-pore (K2P) potassium channels.Expert Opinion: Data from animal models support atrial-ventricular differences in INa kinetics and also suggest atrial-ventricular differences in sodium channel β subunit expression. Further work is required to determine whether intrinsic atrial-ventricular differences in human INa exist or whether functional differences occur due to distinct atrial and ventricular action and resting potentials. SK and K2P channels (particularly K2P 3.1) offer potentially attractive atrial-selective targets. Work is needed to identify the underlying basis of SK current that contributes to (patho)physiological atrial repolarization and settings in which SK inhibition is anti- versus pro-arrhythmic. Although K2P3.1 appears to be a promising target with comparatively selective drugs for experimental use, a lack of selective pharmacology hinders evaluation of other K2P channels as potential atrial-selective targets.
DOI:doi:10.1517/14728222.2016.1159300
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1517/14728222.2016.1159300
 DOI: https://doi.org/10.1517/14728222.2016.1159300
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Atrial fibrillation
 atrial-selective
 fast sodium current
 K2P
 K2P3.1
 SK channel
 SK2
 SK3
 two-pore channel
K10plus-PPN:1696921473
Verknüpfungen:→ Zeitschrift

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