| |  Online-Ressource |
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| Verfasst von: | Harding, Clare R. [VerfasserIn]  |
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| | Egarter, Saskia [VerfasserIn] |
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| | Gow, Matthew [VerfasserIn] |
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| | Jiménez-Ruiz, Elena [VerfasserIn] |
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| | Ferguson, David J. P. [VerfasserIn] |
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| | Meissner, Markus [VerfasserIn] |
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| Titel: | Gliding associated proteins play essential roles during the formation of the inner membrane complex of toxoplasma gondii |
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| Verf.angabe: | Clare R. Harding, Saskia Egarter, Matthew Gow, Elena Jiménez-Ruiz, David J.P. Ferguson, Markus Meissner |
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| E-Jahr: | 2016 |
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| Jahr: | February 4, 2016 |
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| Umfang: | 24 S. |
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| Fussnoten: | Gesehen am 30.04.2020 |
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| Titel Quelle: | Enthalten in: Public Library of SciencePLoS pathogens |
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| Ort Quelle: | Lawrence, Kan. : PLoS, 2005 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 12(2016,2) Artikel-Nummer e1005403, 24 Seiten |
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| ISSN Quelle: | 1553-7374 |
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| Abstract: | The inner membrane complex (IMC) of apicomplexan parasites is a specialised structure localised beneath the parasite’s plasma membrane, and is important for parasite stability and intracellular replication. Furthermore, it serves as an anchor for the myosin A motor complex, termed the glideosome. While the role of this protein complex in parasite motility and host cell invasion has been well described, additional roles during the asexual life cycle are unknown. Here, we demonstrate that core elements of the glideosome, the gliding associated proteins GAP40 and GAP50 as well as members of the GAPM family, have critical roles in the biogenesis of the IMC during intracellular replication. Deletion or disruption of these genes resulted in the rapid collapse of developing parasites after initiation of the cell cycle and led to redistribution of other glideosome components. |
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| DOI: | doi:10.1371/journal.ppat.1005403 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.ppat.1005403 |
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| | Volltext: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005403 |
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| | DOI: https://doi.org/10.1371/journal.ppat.1005403 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biosynthesis |
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| | Cell membranes |
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| | Cellular structures and organelles |
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| | Membrane proteins |
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| | Parasite replication |
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| | Parasitic cell cycles |
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| | Toxoplasma gondii |
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| | Vacuoles |
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| K10plus-PPN: | 1696933773 |
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| Verknüpfungen: | → Zeitschrift |
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Gliding associated proteins play essential roles during the formation of the inner membrane complex of toxoplasma gondii / Harding, Clare R. [VerfasserIn]; February 4, 2016 (Online-Ressource)
