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Verfasst von:Hundeshagen, Gabriel [VerfasserIn]   i
 Cui, Weihua [VerfasserIn]   i
 Musgrove, Lindsay [VerfasserIn]   i
 Cherry, Aaron [VerfasserIn]   i
 Lee, Seung-Jin [VerfasserIn]   i
 Cox, Robert A. [VerfasserIn]   i
 Toliver-Kinsky, Tracy [VerfasserIn]   i
Titel:Fms-Like tyrosine kinase-3 ligand attenuates local and systemic infection in a model of post-burn pneumonia
Verf.angabe:Gabriel Hundeshagen, Weihua Cui, Lindsay Musgrove, Aaron Cherry, Seung-Jin Lee, Robert A. Cox, and Tracy Toliver-Kinsky
E-Jahr:2018
Jahr:June 2018
Umfang:7 S.
Fussnoten:Gesehen am 30.04.2020
Titel Quelle:Enthalten in: Shock
Ort Quelle:Hagerstown, Md. : Lippincott, Williams & Wilkins, 1994
Jahr Quelle:2018
Band/Heft Quelle:49(2018), 6, Seite 721-727
ISSN Quelle:1540-0514
Abstract:Background: - Burn injury induces immunosuppression and promotes infection with opportunistic pathogens. Pneumonia and sepsis are leading causes of post-burn morbidity and mortality. Fms-like tyrosine kinase-3 ligand (Flt3L) improves local and systemic resistance to P aeruginosa-associated burn wound infection. This study evaluates the effects of post-burn prophylactic Flt3L treatment on local and systemic infection and inflammation in a murine model of pneumonia and sepsis. - Methods: - Mice received a severe scald burn, were treated with Flt3L or vehicle (CTR) for 5 days, and inoculated trans-nasally with P aeruginosa. Lung, blood, and spleen were harvested at 24 and 48 h postinoculation (p.i.) to assess infection (bacterial burden, bacteremia, distant organ manifestation) and inflammation (interleukin-6 (IL-6) and myeloperoxidase (MPO) levels). Histology correlated infection and inflammation parameters with morphology. Survival at various bacterial concentrations was monitored for 14 days p.i. - Results: - Bacterial burden was significantly reduced in lung and spleen of Flt3L-treated mice. Flt3L treatment was associated with decreased signs of pulmonary inflammation (reduced wet weight and IL-6 levels), lower incidences of bacteremia and septic distant organ manifestation, and reduced systemic inflammation (IL-6 and MPO). Histologically, reduced alveolar and peribronchiolar neutrophil and lymphocyte infiltration indicated attenuated pulmonary inflammation after Flt3L treatment. Overall survival was comparable between groups for all doses of P aeruginosa, but mortality delayed in the Flt3L-treated group. - Conclusion: - Prophylactic treatment with Flt3L could augment antimicrobial therapy of post-burn pneumonia through improvement of the initial host response to challenge with P aeruginosa, attenuate local, and systemic inflammation as well as septic pathogen dissemination.
DOI:doi:10.1097/SHK.0000000000000964
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/SHK.0000000000000964
 Volltext: https://journals.lww.com/shockjournal/Fulltext/2018/06000/Fms_Like_Tyrosine_Kinase_3_Ligand_Attenuates_Local.15.aspx
 DOI: https://doi.org/10.1097/SHK.0000000000000964
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1696937167
Verknüpfungen:→ Zeitschrift

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