| |  Online-Ressource |
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| Verfasst von: | Merz, Constanze [VerfasserIn]  |
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| | von Mässenhausen, Anne [VerfasserIn] |
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| | Queisser, Angela [VerfasserIn] |
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| | Vogel, Wenzel [VerfasserIn] |
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| | Andrén, Ove [VerfasserIn] |
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| | Kirfel, Jutta [VerfasserIn] |
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| | Duensing, Stefan [VerfasserIn] |
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| | Perner, Sven [VerfasserIn] |
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| | Nowak, Michael [VerfasserIn] |
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| Titel: | IL-6 overexpression in ERG-Positive prostate cancer is mediated by prostaglandin receptor EP2 |
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| Verf.angabe: | Constanze Merz, Anne von Mässenhausen, Angela Queisser, Wenzel Vogel, Ove Andrén, Jutta Kirfel, Stefan Duensing, Sven Perner, and Michael Nowak |
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| E-Jahr: | 2016 |
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| Jahr: | April 2016 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 04.05.2020 |
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| Titel Quelle: | Enthalten in: The American journal of pathology |
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| Ort Quelle: | New York [u.a.] : Elsevier, 1925 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 186(2016), 4, Seite 974-984 |
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| ISSN Quelle: | 1525-2191 |
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| Abstract: | Prostate cancer is the most diagnosed cancer in men and multiple risk factors and genetic alterations have been described. The TMPRSS2-ERG fusion event and the overexpression of the transcription factor ERG are present in approximately 50% of all prostate cancer patients, however, the clinical outcome is still controversial. Prostate tumors produce various soluble factors, including the pleiotropic cytokine IL-6, regulating cellular processes such as proliferation and metastatic segregation. Here, we used prostatectomy samples in a tissue microarray format and analyzed the co-expression and the clinicopathologic data of ERG and IL-6 using immunohistochemical double staining and correlated the read-out with clinicopathologic data. Expression of ERG and IL-6 correlated strongly in prostate tissue samples. Forced expression of ERG in prostate tumor cell lines resulted in significantly increased secretion of IL-6, whereas the down-regulation of ERG decreased IL-6 secretion. By dissecting the underlying mechanism in prostate tumor cell lines we show the ERG-mediated up-regulation of the prostanoid receptors EP2 and EP3. The prostanoid receptor EP2 was overexpressed in human prostate cancer tissue. Furthermore, the proliferation rate and IL-6 secretion in DU145 cells was reduced after treatment with EP2-receptor antagonist. Collectively, our study shows that the expression of ERG in prostate cancer is linked to the expression of IL-6 mediated by the prostanoid receptor EP2. |
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| DOI: | doi:10.1016/j.ajpath.2015.12.009 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ajpath.2015.12.009 |
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| | DOI: https://doi.org/10.1016/j.ajpath.2015.12.009 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Aged |
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| | Biomarkers, Tumor |
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| | Cell Line, Tumor |
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| | Disease-Free Survival |
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| | Down-Regulation |
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| | Gene Expression Regulation, Neoplastic |
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| | Humans |
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| | Interleukin-6 |
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| | Male |
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| | Middle Aged |
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| | Prostate |
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| | Prostatectomy |
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| | Prostatic Neoplasms |
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| | Receptors, Prostaglandin E, EP2 Subtype |
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| | Up-Regulation |
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| K10plus-PPN: | 1697017703 |
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| Verknüpfungen: | → Zeitschrift |
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IL-6 overexpression in ERG-Positive prostate cancer is mediated by prostaglandin receptor EP2 / Merz, Constanze [VerfasserIn]; April 2016 (Online-Ressource)
