Podoplanin as key player of tumor progression and lymph vessel proliferation in ovarian cancer

• Verfasst von: Cobec, Ionut Marcel [VerfasserIn]
• Verfasst von: Sas, Ioan [VerfasserIn]
• Verfasst von: Pirtea, Laurențiu [VerfasserIn]
• Verfasst von: Cimpean, Anca Maria [VerfasserIn]
• Verfasst von: Moatar, Aurica Elisabeta [VerfasserIn]
• Verfasst von: Ceaușu, Raluca Amalia [VerfasserIn]
• Verfasst von: Raica, Marius [VerfasserIn]
• Titel: Podoplanin as key player of tumor progression and lymph vessel proliferation in ovarian cancer
• Verf.angabe: Ionut Marcel Cobec, Ioan Sas, Laurențiu Pirtea, Anca Maria Cimpean, Aurica Elisabeta Moatar, Raluca Amalia Ceaușu and Marius Raica
• E-Jahr: 2016
• Jahr: September 20, 2016
• Umfang: 8 S.
• Fussnoten: Gesehen am 04.05.2020
• Titel Quelle: Enthalten in: Anticancer research
• Ort Quelle: Attiki, 2004
• Jahr Quelle: 2016
• Band/Heft Quelle: 36(2016), 10, Seite 5265-5272
• ISSN Quelle: 1791-7530
• DOI: doi:10.21873/anticanres.11097
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: lymphatic endothelial cells
• Sach-SW: lymphatic metastasis
• Sach-SW: ovarian cancer
• Sach-SW: Podoplanin
• K10plus-PPN: 1697028152

Abstract

Background/Aim: Podoplanin plays a key role in tumor progression and metastasis. We evaluated lymphatics proliferation rate and podoplanin expression in tumor cells of ovarian carcinoma. Materials and Methods: Seventy-five paraffin-embedded specimens of ovarian cancer were immunohistochemically assessed in order to quantify peritumoral (LMVDP) and intratumoral (LMVDT) lymphatic microvessel density of proliferating lymphatics and for podoplanin variability in tumor cells. Results and Conclusion: LMVDT correlated with proliferating tumor vessels located in the peritumoral area (p=0.024) and with the number of mature vessels located in the intratumoral area (p<0.0001), while LMVDP correlated with peritumoral mature vessels (p<0.000l). Proliferating tumor cells at the invasive front were highly positive for podoplanin. To the best of our knowledge, this study represents the first assessment of lymphatic endothelial cell proliferation correlated with podoplanin expression in tumor cells from ovarian cancer. Our data support podoplanin as a potential target that may help reduce ovarian cancer dissemination and lymphatic metastasis.