Glycosidase- and β-lactamase-like activity of dinuclear copper(II) patellamide complexes

• Verfasst von: Comba, Peter [VerfasserIn]
• Verfasst von: Eisenschmidt, Annika [VerfasserIn]
• Verfasst von: Kipper, Nora [VerfasserIn]
• Verfasst von: Schießl, Jasmin [VerfasserIn]
• Titel: Glycosidase- and β-lactamase-like activity of dinuclear copper(II) patellamide complexes
• Verf.angabe: Peter Comba, Annika Eisenschmidt, Nora Kipper, Jasmin Schießl
• E-Jahr: 2016
• Jahr: 13 February 2016
• Umfang: 6 S.
• Fussnoten: Gesehen am 04.05.2020
• Titel Quelle: Enthalten in: Journal of inorganic biochemistry
• Ort Quelle: New York, NY [u.a.] : Elsevier, 1979
• Jahr Quelle: 2016
• Band/Heft Quelle: 159(2016), Seite 70-75
• ISSN Quelle: 1873-3344
• DOI: doi:10.1016/j.jinorgbio.2016.02.014
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Ascidian
• Sach-SW: Copper(II) complexes
• Sach-SW: Cyclic peptides
• Sach-SW: Glycosidase
• Sach-SW: Lactamase
• Sach-SW: Prochloron
• K10plus-PPN: 1697036643

Abstract

Prochloron, a blue-green algae belonging to ancient prokaryotes, produces, like other cyanobacteria, cyclic pseudo-peptides, which are also found in its obligate symbiont ascidiae (Lissoclinum patellum). Although research has focused for some time on the putative metabolic function of these cyclic peptides, to date it is still not understood. Their role might be connected to the increased concentrations of divalent metal ions, especially CuII, found in ascidiae. Dinuclear copper(II) complexes of cyclic pseudo-peptides revealed a broad hydrolytic capacity, including carboanhydrase and phosphatase activity. This study reports their β-lactamase as well as α- and β-glycosidase activity with kcat=(11.34±0.91)ˑ10−4s−1 for β-lactamase, kcat=(1.55±0.13)ˑ10−4s−1 for α-glycosidase and kcat=(1.22±0.09)ˑ10−4s−1 for β-glycosidase activity.