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Verfasst von:Möckel, Martin [VerfasserIn]   i
 Slagman, Anna [VerfasserIn]   i
 Vollert, Jörn Ole [VerfasserIn]   i
 Ebmeyer, Stefan [VerfasserIn]   i
 Wiemer, Jan C. [VerfasserIn]   i
 Searle, Julia [VerfasserIn]   i
 Giannitsis, Evangelos [VerfasserIn]   i
 Kellum, John A. [VerfasserIn]   i
 Maisel, Alan [VerfasserIn]   i
Titel:Rationale and design of the IMPACT EU-trial
Titelzusatz:improve management of heart failure with procalcitonin biomarkers in cardiology (BIC)-18
Verf.angabe:Martin Möckel, Anna Slagman, Jörn Ole Vollert, Stefan Ebmeyer, Jan C. Wiemer, Julia Searle, Evangelos Giannitsis, John A. Kellum, Alan Maisel
E-Jahr:2018
Jahr:8 January 2018
Umfang:7 S.
Fussnoten:Gesehen am 05.05.2020
Titel Quelle:Enthalten in: Biomarkers
Ort Quelle:London : Taylor & Francis, 1996
Jahr Quelle:2018
Band/Heft Quelle:23(2018), 1, Seite 97-103
ISSN Quelle:1366-5804
Abstract:OBJECTIVES: To evaluate the effectiveness of procalcitonin (PCT)-guided antibiotic treatment compared to current treatment practice to reduce 90-day all-cause mortality in emergency patients with shortness of breath (SOB) and suspected acute heart failure (AHF). - BACKGROUND: Concomitant AHF and lower respiratory tract (or other bacterial) infection in emergency patients with dyspnea are common and can be difficult to diagnose. Early and adequate initiation of antibiotic therapy (ABX) significantly improves patient outcome, but superfluous prescription of ABX maybe harmful. - METHODS: In a multicentre, prospective, randomized, controlled process trial with an open intervention, adult emergency patients with SOB and increased levels of natriuretic peptides will be randomized to either a standard care group or a PCT-guided group with respect to the initiation of antibiotic treatment. In the PCT-guided group, the initiation of antibiotic therapy is based on the results of acute PCT measurements at admission, using a cut-off of 0.2 ng/ml. A two-stage sample-size adaptive design is used; an interim analysis was done after completion of 50% of patients and the final sample size remained unchanged. Primary endpoint is 90-day all-cause mortality. - CONCLUSIONS: The current study will provide evidence, whether the routine use of PCT in patients with suspected AHF improves outcome.
DOI:doi:10.1080/1354750X.2017.1420823
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1080/1354750X.2017.1420823
 DOI: https://doi.org/10.1080/1354750X.2017.1420823
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Acute heart failure
 Adult
 Anti-Bacterial Agents
 antibiotic therapy
 Bacterial Infections
 Biomarkers
 Calcitonin
 Dyspnea
 Emergency Service, Hospital
 Female
 Heart Failure
 Humans
 Male
 Outcome Assessment, Health Care
 procalcitonin
 Proportional Hazards Models
 Prospective Studies
 Research Design
K10plus-PPN:1697203701
Verknüpfungen:→ Zeitschrift

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