| |  Online-Ressource |
|---|
| Verfasst von: | Belskaya, Nataliya P. [VerfasserIn]  |
|---|
| | Lugovik, Kseniya I. [VerfasserIn] |
|---|
| | Bakulev, Vasiliy A. [VerfasserIn] |
|---|
| | Bauer, Jenny [VerfasserIn] |
|---|
| | Kitanovic, Igor [VerfasserIn] |
|---|
| | Holenya, Pavlo [VerfasserIn] |
|---|
| | Zakhartsev, Maksim [VerfasserIn] |
|---|
| | Wölfl, Stefan [VerfasserIn] |
|---|
| Titel: | The new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity |
|---|
| Verf.angabe: | Nataliya P. Belskaya, Kseniya I. Lugovik, Vasiliy A. Bakulev, Jenny Bauer, Igor Kitanovic, Pavlo Holenya, Maksim Zakhartsev, Stefan Wölfl |
|---|
| Jahr: | 2016 |
|---|
| Jahr des Originals: | 2015 |
|---|
| Umfang: | 18 S. |
|---|
| Fussnoten: | Online 11 November 2015 ; Gesehen am 05.05.2020 |
|---|
| Titel Quelle: | Enthalten in: European journal of medicinal chemistry |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1987 |
|---|
| Jahr Quelle: | 2016 |
|---|
| Band/Heft Quelle: | 108(2016), Seite 245-257 |
|---|
| ISSN Quelle: | 1768-3254 |
|---|
| Abstract: | A series of 4H-1,2,3-thiadiazolo[5,4-b]indoles were synthesized by novel tandem of oxidative cyclization of 3-alkoxycarbonylhydrazonoindoline-2-thiones, 1,5-H-shift and elimination of tert-butoxy(ethoxy)carbonyl group. The simple method for their modifications by the reactions with electrophilic agents were elaborated and as a result of the synthetic investigation a number of N-alkyl-, N-acyl- and N-sulfonyl-4H-1,2,3-thiadiazolo[5,4-b]indoles were prepared in good yields. Preliminary biological tests for the three examples of synthesized compounds with different substituents at the nitrogen atom indole ring have shown that the biological behavior of the investigated 1,2,3-thiadiazolo[5,4-b]indoles is substantially directed by this structural fragment. |
|---|
| DOI: | doi:10.1016/j.ejmech.2015.11.011 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.ejmech.2015.11.011 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0223523415303482 |
|---|
| | DOI: https://doi.org/10.1016/j.ejmech.2015.11.011 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | 3-Hydrazonoindoline-2-thiones |
|---|
| | Antiproliferative activity |
|---|
| | Apoptosis induction |
|---|
| | Oxidative cyclization |
|---|
| K10plus-PPN: | 1697216196 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬The¬ new facile and straightforward method for the synthesis of 4H-1,2,3-thiadiazolo[5,4-b]indoles and determination of their antiproliferative activity / Belskaya, Nataliya P. [VerfasserIn]; 2016 (Online-Ressource)
