No longer a nuisance

• Verfasst von: Rošić, Silvana [VerfasserIn]
• Verfasst von: Erhardt, Sylvia [VerfasserIn]
• Titel: No longer a nuisance
• Titelzusatz: long non-coding RNAs join CENP-A in epigenetic centromere regulation
• Verf.angabe: Silvana Rošić, Sylvia Erhardt
• E-Jahr: 2016
• Jahr: 9 January 2016
• Umfang: 12 S.
• Fussnoten: Gesehen am 05.05.2020
• Titel Quelle: Enthalten in: Cellular and molecular life sciences
• Ort Quelle: Cham (ZG) : Springer International Publishing AG, 1997
• Jahr Quelle: 2016
• Band/Heft Quelle: 73(2016), 7, Seite 1387-1398
• ISSN Quelle: 1420-9071
• DOI: doi:10.1007/s00018-015-2124-7
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1697225853

Abstract

Centromeres represent the basis for kinetochore formation, and are essential for proper chromosome segregation during mitosis. Despite these essential roles, centromeres are not defined by specific DNA sequences, but by epigenetic means. The histone variant CENP-A controls centromere identity epigenetically and is essential for recruiting kinetochore components that attach the chromosomes to the mitotic spindle during mitosis. Recently, a new player in centromere regulation has emerged: long non-coding RNAs transcribed from repetitive regions of centromeric DNA function in regulating centromeres epigenetically. This review summarizes recent findings on the essential roles that transcription, pericentromeric transcripts, and centromere-derived RNAs play in centromere biology.