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| Verfasst von: | Roth, Susanne [VerfasserIn]  |
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| | Bergmann, Hanna [VerfasserIn] |
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| | Jaeger, Martin [VerfasserIn] |
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| | Yeroslaviz, Assa [VerfasserIn] |
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| | Neumann, Konstantin [VerfasserIn] |
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| | Koenig, Paul-Albert [VerfasserIn] |
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| | Prazeres da Costa, Clarissa [VerfasserIn] |
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| | Vanes, Lesley [VerfasserIn] |
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| | Kumar, Vinod [VerfasserIn] |
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| | Johnson, Melissa [VerfasserIn] |
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| | Menacho-Márquez, Mauricio [VerfasserIn] |
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| | Habermann, Bianca [VerfasserIn] |
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| | Tybulewicz, Victor L. [VerfasserIn] |
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| | Netea, Mihai [VerfasserIn] |
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| | Bustelo, Xosé R. [VerfasserIn] |
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| | Ruland, Jürgen [VerfasserIn] |
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| Titel: | Vav proteins are key regulators of Card9 signaling for innate antifungal immunity |
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| Verf.angabe: | Susanne Roth, Hanna Bergmann, Martin Jaeger, Assa Yeroslaviz, Konstantin Neumann, Paul-Albert Koenig, Clarissa Prazeres da Costa, Lesley Vanes, Vinod Kumar, Melissa Johnson, Mauricio Menacho-Márquez, Bianca Habermann, Victor L. Tybulewicz, Mihai Netea, Xosé R. Bustelo, and Jürgen Ruland |
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| E-Jahr: | 2016 |
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| Jahr: | December 6, 2016 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 05.05.2020 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 17(2016), 10, Seite 2572-2583 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Fungal infections are major causes of morbidity and mortality, especially in immunocompromised individuals. The innate immune system senses fungal pathogens through Syk-coupled C-type lectin receptors (CLRs), which signal through the conserved immune adaptor Card9. Although Card9 is essential for antifungal defense, the mechanisms that couple CLR-proximal events to Card9 control are not well defined. Here, we identify Vav proteins as key activators of the Card9 pathway. Vav1, Vav2, and Vav3 cooperate downstream of Dectin-1, Dectin-2, and Mincle to engage Card9 for NF-κB control and proinflammatory gene transcription. Although Vav family members show functional redundancy, Vav1/2/3−/− mice phenocopy Card9−/− animals with extreme susceptibility to fungi. In this context, Vav3 is the single most important Vav in mice, and a polymorphism in human VAV3 is associated with susceptibility to candidemia in patients. Our results reveal a molecular mechanism for CLR-mediated Card9 regulation that controls innate immunity to fungal infections. |
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| DOI: | doi:10.1016/j.celrep.2016.11.018 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.celrep.2016.11.018 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2211124716315741 |
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| | DOI: https://doi.org/10.1016/j.celrep.2016.11.018 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1697231799 |
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| Verknüpfungen: | → Zeitschrift |
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Vav proteins are key regulators of Card9 signaling for innate antifungal immunity / Roth, Susanne [VerfasserIn]; December 6, 2016 (Online-Ressource)
