| |  Online-Ressource |
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| Verfasst von: | Daniel, Volker [VerfasserIn]  |
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| | Sadeghi, Mahmoud [VerfasserIn] |
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| | Süsal, Caner [VerfasserIn] |
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| | Scherer, Sabine [VerfasserIn] |
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| | Tran, Hien Nicole [VerfasserIn] |
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| | Gombos, Petra [VerfasserIn] |
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| | Trojan, Karina [VerfasserIn] |
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| | Morath, Christian [VerfasserIn] |
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| | Opelz, Gerhard [VerfasserIn] |
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| Titel: | Clinical relevance of preformed IgG and IgM antibodies against donor endothelial progenitor cells in recipients of living donor kidney grafts |
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| Verf.angabe: | Volker Daniel, Mahmoud Sadeghi, Caner Suesal, Sabine Scherer, Hien Tran, Petra Gombos, Karina Trojan, Christian Morath, Gerhard Opelz |
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| Jahr: | 2016 |
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| Jahr des Originals: | 2015 |
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| Umfang: | 7 S. |
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| Fussnoten: | First published: 05 November 2015 ; Gesehen am 06.05.2020 |
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| Titel Quelle: | Enthalten in: Clinical transplantation |
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| Ort Quelle: | Oxford [u.] : Wiley-Blackwell, 1999 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 30(2016), 2, Seite 124-130 |
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| ISSN Quelle: | 1399-0012 |
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| Abstract: | Background Literature reports suggest that non-HLA-antibodies against human endothelial progenitor cells (EPC) can be detected in pre-transplant recipient serum and that EPC antibodies can have a deleterious influence on the graft. Methods We investigated 71 renal transplant recipients from living donors for a possible influence of pre-transplant donor-specific IgG and/or IgM recipient antibodies against EPC of the donor using the flow cytometric XM-ONE cross-match. Results Eight of the 71 patients developed acute biopsy-proven rejection. Two of these patients showed IgM antibodies against EPC prior to transplantation while the other six patients had neither IgG nor IgM EPC antibodies. Conversely, pre-transplant IgG or IgM antibodies against EPC were detected in 19 patients without acute rejection (3 × both IgG and IgM, 1 × IgG and 15 × IgM). The remaining 44 patients had neither EPC antibodies nor experienced rejection. Comparing serum creatinine levels at one month and one yr post-transplant within and among the three patient groups revealed that serum creatinine levels were similar in patients with or without EPC antibodies (p > 0.05). Conclusion In this series of 71 recipients with living donor kidneys, pre-transplant EPC antibodies detected with the XM-ONE test kit were neither associated with acute rejection nor with graft function at one month or one yr. |
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| DOI: | doi:10.1111/ctr.12665 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/ctr.12665 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.12665 |
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| | DOI: https://doi.org/10.1111/ctr.12665 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | antibodies against endothelial progenitor cells |
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| | graft dysfunction |
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| | living donor kidney grafts |
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| | preformed EPC antibodies |
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| | rejection |
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| | XM-ONE |
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| K10plus-PPN: | 1697297706 |
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| Verknüpfungen: | → Zeitschrift |
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Clinical relevance of preformed IgG and IgM antibodies against donor endothelial progenitor cells in recipients of living donor kidney grafts / Daniel, Volker [VerfasserIn]; 2016 (Online-Ressource)
