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Verfasst von:Mall, Marcus A. [VerfasserIn]   i
 Stahl, Mirjam [VerfasserIn]   i
 Gräber, Simon Y. [VerfasserIn]   i
 Sommerburg, Olaf [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Wielpütz, Mark Oliver [VerfasserIn]   i
Titel:Early detection and sensitive monitoring of CF lung disease
Titelzusatz:prospects of improved and safer imaging
Verf.angabe:Marcus A. Mall, Mirjam Stahl, Simon Y. Graeber, Olaf Sommerburg, Hans-Ulrich Kauczor, and Mark O. Wielpütz
E-Jahr:2016
Jahr:23 September 2016
Umfang:12 S.
Fussnoten:Gesehen am 06.05.2020
Titel Quelle:Enthalten in: Pediatric pulmonology
Ort Quelle:New York, NY [u.a.] : Wiley-Liss, 1985
Jahr Quelle:2016
Band/Heft Quelle:51(2016), S44, Seite S49-S60
ISSN Quelle:1099-0496
Abstract:Recent imaging studies using chest computed tomography (CT) in presymptomatic infants and young children with cystic fibrosis (CF) diagnosed by newborn screening presented compelling evidence of early onset and progression of structural lung damage in CF. These data argue persuasively that non-invasive outcome measures for early detection and sensitive monitoring of lung disease applicable in the clinical setting will be instrumental for further improvement of clinical care and the development of early intervention therapies that have the potential to prevent irreversible lung damage. In this context, the use of CT imaging for early detection and long-term monitoring has the disadvantage of the risk to induce malignancies due to cumulating ionizing radiation exposure. More recently, magnetic resonance imaging (MRI) has emerged as an alternative radiation-free imaging technique for quantitative assessment of CF lung disease. In addition to structural lung damage, chest MRI enables non-invasive assessment of abnormalities in lung perfusion and ventilation characteristically associated with mucus plugging in CF lung disease. Here, we review recent developments and the prospects of MRI for improved and safer imaging with a focus on recent studies that support its utility as a sensitive non-invasive outcome measure of early lung disease in young children with CF. Pediatr Pulmonol. 2016;51:S49-S60. © 2016 Wiley Periodicals, Inc.
DOI:doi:10.1002/ppul.23537
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/ppul.23537
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.23537
 DOI: https://doi.org/10.1002/ppul.23537
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cystic fibrosis
 lung disease
 lung perfusion
 lung structure
 magnetic resonance imaging
K10plus-PPN:169730236X
Verknüpfungen:→ Zeitschrift

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