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Status: Bibliographieeintrag

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Verfasst von:Kalaghatgi, Prabhav [VerfasserIn]   i
 Sikorski, Anna Maria [VerfasserIn]   i
 Knops, Elena [VerfasserIn]   i
 Rupp, Daniel [VerfasserIn]   i
 Sierra, Saleta [VerfasserIn]   i
 Heger, Eva [VerfasserIn]   i
 Neumann-Fraune, Maria [VerfasserIn]   i
 Beggel, Bastian [VerfasserIn]   i
 Walker, Andreas [VerfasserIn]   i
 Timm, Jörg [VerfasserIn]   i
 Walter, Hauke [VerfasserIn]   i
 Obermeier, Martin [VerfasserIn]   i
 Kaiser, Rolf [VerfasserIn]   i
 Bartenschlager, Ralf [VerfasserIn]   i
 Lengauer, Thomas [VerfasserIn]   i
Titel:Geno2pheno(HCV) - a web-based interpretation system to support Hepatitis C treatment decisions in the era of direct-acting antiviral agents
Verf.angabe:Prabhav Kalaghatgi, Anna Maria Sikorski, Elena Knops, Daniel Rupp, Saleta Sierra, Eva Heger, Maria Neumann-Fraune, Bastian Beggel, Andreas Walker, Jörg Timm, Hauke Walter, Martin Obermeier, Rolf Kaiser, Ralf Bartenschlager, Thomas Lengauer
E-Jahr:2016
Jahr:May 19, 2016
Umfang:16 S.
Illustrationen:Illustrationen
Fussnoten:(HCV) ist im Titel tiefgestellt ; Gesehen am 07.05.2020
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2016
Band/Heft Quelle:11(2016,5) Artikel-Nummer e0155869, 16 Seiten
ISSN Quelle:1932-6203
Abstract:The face of hepatitis C virus (HCV) therapy is changing dramatically. Direct-acting antiviral agents (DAAs) specifically targeting HCV proteins have been developed and entered clinical practice in 2011. However, despite high sustained viral response (SVR) rates of more than 90%, a fraction of patients do not eliminate the virus and in these cases treatment failure has been associated with the selection of drug resistance mutations (RAMs). RAMs may be prevalent prior to the start of treatment, or can be selected under therapy, and furthermore they can persist after cessation of treatment. Additionally, certain DAAs have been approved only for distinct HCV genotypes and may even have subtype specificity. Thus, sequence analysis before start of therapy is instrumental for managing DAA-based treatment strategies. We have created the interpretation system geno2pheno[HCV] (g2p[HCV]) to analyse HCV sequence data with respect to viral subtype and to predict drug resistance. Extensive reviewing and weighting of literature related to HCV drug resistance was performed to create a comprehensive list of drug resistance rules for inhibitors of the HCV protease in non-structural protein 3 (NS3-protease: Boceprevir, Paritaprevir, Simeprevir, Asunaprevir, Grazoprevir and Telaprevir), the NS5A replicase factor (Daclatasvir, Ledipasvir, Elbasvir and Ombitasvir), and the NS5B RNA-dependent RNA polymerase (Dasabuvir and Sofosbuvir). Upon submission of up to eight sequences, g2p[HCV] aligns the input sequences, identifies the genomic region(s), predicts the HCV geno- and subtypes, and generates for each DAA a drug resistance prediction report. g2p[HCV] offers easy-to-use and fast subtype and resistance analysis of HCV sequences, is continuously updated and freely accessible under http://hcv.geno2pheno.org/index.php. The system was partially validated with respect to the NS3-protease inhibitors Boceprevir, Telaprevir and Simeprevir by using data generated with recombinant, phenotypic cell culture assays obtained from patients’ virus variants.
DOI:doi:10.1371/journal.pone.0155869
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0155869
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155869
 DOI: https://doi.org/10.1371/journal.pone.0155869
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Amino acid sequence analysis
 Antimicrobial resistance
 Drug licensing
 Hepatitis C virus
 Multiple alignment calculation
 Sequence alignment
 Sequence analysis
 Substitution mutation
K10plus-PPN:1697637566
Verknüpfungen:→ Zeitschrift

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