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Verfasst von:Kann, Oliver [VerfasserIn]   i
Titel:The interneuron energy hypothesis
Titelzusatz:Implications for brain disease
Verf.angabe:Oliver Kann
E-Jahr:2016
Jahr:[2016]
Jahr des Originals:2015
Umfang:11 S.
Fussnoten:Available online 16 August 2015 ; Gesehen am 07.05.2020
Titel Quelle:Enthalten in: Neurobiology of disease
Ort Quelle:Orlando, Fla. : Academic Press, 1994
Jahr Quelle:2016
Band/Heft Quelle:90(2016), Seite 75-85
ISSN Quelle:1095-953X
Abstract:Fast-spiking, inhibitory interneurons - prototype is the parvalbumin-positive (PV+) basket cell - generate action potentials at high frequency and synchronize the activity of numerous excitatory principal neurons, such as pyramidal cells, during fast network oscillations by rhythmic inhibition. For this purpose, fast-spiking, PV+ interneurons have unique electrophysiological characteristics regarding action potential kinetics and ion conductances, which are associated with high energy expenditure. This is reflected in the neural ultrastructure by enrichment with mitochondria and cytochrome c oxidase, indicating the dependence on oxidative phosphorylation for adenosine-5′-triphosphate (ATP) generation. The high energy expenditure is most likely required for membrane ion transport in dendrites and the extensive axon arbor as well as for presynaptic release of neurotransmitter, gamma-aminobutyric acid (GABA). Fast-spiking, PV+ interneurons are central for the emergence of gamma oscillations (30-100Hz) that provide a fundamental mechanism of complex information processing during sensory perception, motor behavior and memory formation in networks of the hippocampus and the neocortex. Conversely, shortage in glucose and oxygen supply (metabolic stress) and/or excessive formation of reactive oxygen and nitrogen species (oxidative stress) may render these interneurons to be a vulnerable target. Dysfunction in fast-spiking, PV+ interneurons might set a low threshold for impairment of fast network oscillations and thus higher brain functions. This pathophysiological mechanism might be highly relevant for cerebral aging as well as various acute and chronic brain diseases, such as stroke, vascular cognitive impairment, epilepsy, Alzheimer's disease and schizophrenia.
DOI:doi:10.1016/j.nbd.2015.08.005
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.nbd.2015.08.005
 Volltext: http://www.sciencedirect.com/science/article/pii/S0969996115300255
 DOI: https://doi.org/10.1016/j.nbd.2015.08.005
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Basket cell
 Brain energy metabolism
 Cognition
 Electrophysiology
 Mitochondria
 Neural gamma oscillations
 Neurodegeneration
 Oxidative stress
 ROS
 Synaptic inhibition
K10plus-PPN:1697653693
Verknüpfungen:→ Zeitschrift

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