Go in! Go out! Inducible control of nuclear localization

• Verfasst von: Di Ventura, Barbara [VerfasserIn]
• Verfasst von: Kuhlman, Brian [VerfasserIn]
• Titel: Go in! Go out! Inducible control of nuclear localization
• Verf.angabe: Barbara Di Ventura and Brian Kuhlman
• E-Jahr: 2016
• Jahr: 30th June 2016
• Umfang: 10 S.
• Fussnoten: Gesehen am 07.05.2020
• Titel Quelle: Enthalten in: Current opinion in chemical biology
• Ort Quelle: London : Current Biology Ltd., 1997
• Jahr Quelle: 2016
• Band/Heft Quelle: 34(2016), Seite 62-71
• ISSN Quelle: 1879-0402
• DOI: doi:10.1016/j.cbpa.2016.06.009
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1697671411

Abstract

Cells have evolved a variety of mechanisms to regulate the enormous complexity of processes taking place inside them. One mechanism consists in tightly controlling the localization of macromolecules, keeping them away from their place of action until needed. Since a large fraction of the cellular response to external stimuli is mediated by gene expression, it is not surprising that transcriptional regulators are often subject to stimulus-induced nuclear import or export. Here we review recent methods in chemical biology and optogenetics for controlling the nuclear localization of proteins of interest inside living cells. These methods allow researchers to regulate protein activity with exquisite spatiotemporal control, and open up new possibilities for studying the roles of proteins in a broad array of cellular processes and biological functions.