| |  Online-Ressource |
|---|
| Verfasst von: | Mauceri, Daniela [VerfasserIn]  |
|---|
| | Buchthal, Bettina [VerfasserIn] |
|---|
| | Hemstedt, Thekla Joana [VerfasserIn] |
|---|
| | Weiss, Ursula [VerfasserIn] |
|---|
| | Klein, Christian D. [VerfasserIn] |
|---|
| | Bading, Hilmar [VerfasserIn] |
|---|
| Titel: | Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage |
|---|
| Verf.angabe: | Daniela Mauceri, Bettina Buchthal, Thekla J. Hemstedt, Ursula Weiss, Christian D. Klein, and Hilmar Bading |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | March 30, 2020 |
|---|
| Umfang: | 8 S. |
|---|
| Fussnoten: | Gesehen am 07.05.2018 |
|---|
| Titel Quelle: | Enthalten in: National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America |
|---|
| Ort Quelle: | Washington, DC : National Acad. of Sciences, 1915 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 117(2020), 15, Seite 8616-8623 |
|---|
| ISSN Quelle: | 1091-6490 |
|---|
| Abstract: | In the adult brain, vascular endothelial growth factor D (VEGFD) is required for structural integrity of dendrites and cognitive abilities. Alterations of dendritic architectures are hallmarks of many neurologic disorders, including stroke-induced damage caused by toxic extrasynaptic NMDA receptor (eNMDAR) signaling. Here we show that stimulation of eNMDARs causes a rapid shutoff of VEGFD expression, leading to a dramatic loss of dendritic structures. Using the mouse middle cerebral artery occlusion (MCAO) stroke model, we have established the therapeutic potential of recombinant mouse VEGFD delivered intraventricularly to preserve dendritic architecture, reduce stroke-induced brain damage, and facilitate functional recovery. An easy-to-use therapeutic intervention for stroke was developed that uses a new class of VEGFD-derived peptide mimetics and postinjury nose-to-brain delivery. |
|---|
| DOI: | doi:10.1073/pnas.2001563117 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1073/pnas.2001563117 |
|---|
| | Volltext: https://www.pnas.org/content/117/15/8616 |
|---|
| | DOI: https://doi.org/10.1073/pnas.2001563117 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | dendrite |
|---|
| | extrasynaptic NMDA receptor |
|---|
| | nose-to-brain delivery |
|---|
| | stroke |
|---|
| | VEGFD |
|---|
| K10plus-PPN: | 1697676715 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage / Mauceri, Daniela [VerfasserIn]; March 30, 2020 (Online-Ressource)
